Solubility Enhancement of Etoricoxib by Cosolvency Approach

Table 2

Solubility profile of etoricoxib in water-PEG 400 mixture at room temperature.

Water (% v/v)	Polyethylene glycol 400 (% v/v)	Dielectric constant	Solubility of etoricoxib (𝑆𝑚, mg/mL) (Mean ± S.D., 𝑛=3)
0	100	12.50	2.1918±0.0828
10	90	19.00	2.0840±0.0607
20	80	25.59	1.7664±0.0552
30	70	32.19	1.4311±0.0417
40	60	38.78	1.1682±0.0312
50	50	45.38	0.8329±0.0210
60	40	51.98	0.6044±0.0098
70	30	58.57	0.3757±0.0066
80	20	65.17	0.2708±0.0043
90	10	71.76	0.1590±0.0037
100	0	78.36	0.0767±0.0018