Research Article
Solubility Enhancement of Etoricoxib by Cosolvency Approach
Table 3
Solubility profile of etoricoxib in water-PG mixture at room temperature.
| Water (% v/v) | PG (% v/v) | Dielectric constant | Solubility of etoricoxib (, mg/mL) (Mean ± S.D., ) |
| 0 | 100 | 32.00 | | 10 | 90 | 36.64 | | 20 | 80 | 41.27 | | 30 | 70 | 45.91 | | 40 | 60 | 50.54 | | 50 | 50 | 55.18 | | 60 | 40 | 59.82 | | 70 | 30 | 64.45 | | 80 | 20 | 69.09 | | 90 | 10 | 73.72 | | 100 | 0 | 78.36 | |
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