Matrix Metalloproteinases-9 (MMPs-9) and -12 Are Upregulated in the Airways of Mice with Chronic Airway Inflammation and Remodeling

Figure 4

Upregulations of MMPs-9 and -12 in BALFs of the repeatedly antigen challenged mice. The bands corresponding to the proenzyme of MMP-9 (98 kD) (a), the proenzyme (54 kD) and intermediate form (45 kD) of MMP-12 (b) were detected by western blot. The expressions of MMPs-9 and -12 were persistently increased after repeated antigen challenges from day 24 to day 54, and significantly upregulated at day 54. Each column represents the mean with SEM from 3 to 4 independent experiments. ^∗𝑃<0.05,^∗∗𝑃<0.01 versus sensitized by Bonferroni/Dunn.

(a)

(b)