Nephroprotective Effect of POLYCAN on Acute Renal Failure Induced by Cisplatin in Rats

Table 3

Change on the serum BUN and creatinine level.

group	Sham control	Vehicle control	CAPT	P 31.25	P 62.5	P 125	LOSA
Serum BUN (mg/dL)
Day 0^1	16.91±1.99	16.89±1.53	17.05±2.72	16.83±1.97	17.00±2.30	16.86±1.53	16.88±2.16
Day 28^2	20.24±1.81	20.10±1.53	18.24±1.18^**,##	18.33±1.68^**,##	18.24±1.69 **	17.38±1.47^*,#	17.25±1.45^*,#
Day 33^3	19.93±1.87	205.98±98.27 *	94.53±59.63^*,#	72.66±56.77^#	66.20±50.54^**,#	63.11±32.39^*,#	77.34±48.68^*,#
Serum creatinine (mg/dL)
Day 0^1	0.55±0.05	0.57±0.03	0.58±0.04	0.56±0.05	0.56±0.03	0.56±0.03	0.57±0.03
Day 28^2	0.63±0.05	0.65±0.05	0.62±0.02	0.61±0.04^##	0.59±0.03^##	0.58±0.03^**,#	0.60±0.03^##
Day 33^3	0.66±0.06	3.76±2.41 *	1.65±0.83^*,#	1.46±0.72^*,#	1.30±0.64^*,#	1.19±0.39^*,#	1.60±0.98^*,#

𝑛=8; (Mean ± S.D.), ¹first administration day of test article, ²at CDDP administration day, ³at euthanasia; *𝑃<0.01 and **𝑃<0.05 compared to sham by MW test; ^#𝑃<0.01 and ^##𝑃<0.05 compared to vehicle control by MW test.