The Major Histocompatibility Complex in Bovines: A Review

Table 2

Association of the BoLA-DRB3.2 alleles with different diseases in different breeds of cattle.

Disease	Breed	BoLA allele	Type of association (resistance/susceptibility)
Dermatophilosis	Brahman^a'	BoLA-A8, BoLA-DRB3 “EIAY”	Higher resistance
Severe mastitis	Canadian Holstein^b'	BoLA-DRB3.2*23	Higher susceptibility
Retained placenta	Canadian Holstein^b'	BoLA-DRB3.2*03	Lower susceptibility
Subclinical mastitis	Iranian Holstein^c'	BoLA-DRB3.2*08	Higher susceptibility
Tick infestation by Amblomma americanum	Bos taurus x Bos indicus ^d'	DRB3*4401	Resistance
Clinical mastitis	Canadian Holstein^e'	DRB3.2*03, DRB3.2*11	Lower susceptibility
Clinical mastitis	Canadian Holstein^e'	DRB3.2*08	Higher susceptibility
Clinical mastitis	Norwegian Red^f'	DRB3.2*13, *18, *22 and *27	Lower susceptibility
Mastitis	Japanese Holstein^g',h'	DRB3*0101, *1501	Susceptibility
Mastitis	Japanese Holstein^g',h'	DRB3*1101, *1401, *1201	Resistance
Lymphosarcoma and persistent lymphocytosis caused by Bovine Leukemia virus	Holstein^i'	BoLA DRB3.2*11 subtype ISAG*0902	Resistance
Leukemia	Russian Black Pied^j'	BoLA-DRB3.2*11, *23 and *28	Resistance

^a'Maillard et al. [127], ^b'Sharif et al. [108], ^c'Pashmi et al. [122], ^d'Untalan et al. [128], ^e'Rupp et al. [129], ^f'Kulberg et al. [118], ^g',h'Yoshida et al. [125, 130], ^i'Juliarena et al. [131], ^j'Sulimova et al. [132].