Table 3: Anti-inflammatory activity and toxicity data of di- and triorganotin(IV) derivatives of (5′-GMP)^{2−}.

Complex/standard drug

Anti-inflammatory activity^{a}

Toxicity LD_{50}

Dose (mg/kg p.o.)

% inhibition

mg/kg p.o.

Me_{2}Sn(5′-GMP)·H_{2}O

40

18.12

>400

n-Bu_{2}Sn(5′-GMP)·H_{2}O

40

16.32

>400

Ph_{2}Sn(5′-GMP)·H_{2}O

40

19.22

>400

(i-Pr_{3}Sn)_{2}(5′-GMP)·H_{2}O

40

15.64

>400

(n-Bu_{3}Sn)_{2}(5′-GMP)·H_{2}O

40

17.34

>400

(Ph_{3}Sn)_{2}(5′-GMP)·H_{2}O

40

20.63

>400

Phenyl butazone

40

34.56

>2000

^{
a}% inhibition in paw edema = , where DT and DC are the mean volumes of paw edema in drug-treated and control groups. Standard deviation in DC is <0.09 and in DT <0.15. Standard error in mean in DC is <0.040 and in DT <0.067.