Research Article

Formulation and In Vitro Evaluation of Ufasomes for Dermal Administration of Methotrexate

Table 1

Size and entrapment efficiency of the prepared oleic acid vesicles.

Formulation codeOleic acid: 5-MTX (molar ratio)Entrapment efficiencyParticle size (nm)PDI

UF-19 : 1( 3 9 . 4 ± 2 . 1 )505 ± 15 0 . 3 6 7 ± 0 . 0 3 7
UF-28 : 2( 4 5 . 4 ± 2 . 1 )523 ± 12 0 . 4 6 8 ± 0 . 0 3 7
UF-37 : 3( 5 1 . 0 ± 4 . 2 %),632 ± 17 0 . 2 6 2 ± 0 . 0 3 7
UF-46 : 4( 4 9 . 4 ± 2 . 7 )531 ± 16 0 . 4 8 9 ± 0 . 0 3 7
UF-55 : 5( 4 8 . 4 ± 2 . 4 )404 ± 13 0 . 5 8 1 ± 0 . 0 3 7

UF-1,2,3-ufasomes with different molar ratio of drug.