- About this Journal ·
- Aims and Scope ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Volume 2012 (2012), Article ID 876203, 5 pages
The Role of Granulysin in Cancer Immunology
Department of Internal Medicine, Ichikawa General Hospital, Tokyo Dental College, 5-11-13 Sugano, Ichikawa 272-8513, Japan
Received 4 August 2011; Accepted 2 October 2011
Academic Editors: B. Stijlemans and A. B. Van Spriel
Copyright © 2012 Satoshi Okada and Tetsuo Morishita. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- J. H. Russell and T. J. Ley, “Lymphocyte-mediated cytotoxicity,” Annual Review of Immunology, vol. 20, pp. 323–370, 2002.
- D. Kagi, B. Ledermann, K. Burki et al., “Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice,” Nature, vol. 369, no. 6475, pp. 31–37, 1994.
- S. Balkow, A. Kersten, T. T. T. Tran et al., “Concerted action of the FasL/Fas and perforin/granzyme A and B pathways is mandatory for the development of early viral hepatitis but not for recovery from viral infection,” Journal of Virology, vol. 75, no. 18, pp. 8781–8791, 2001.
- C. Clayberger and A. M. Krensky, “Granulysin,” Current Opinion in Immunology, vol. 15, no. 5, pp. 560–565, 2003.
- S. Stenger, D. A. Hanson, R. Teitelbaum et al., “An antimicrobial activity of cytolytic T cells mediated by granulysin,” Science, vol. 282, no. 5386, pp. 121–125, 1998.
- S. Stenger, J. P. Rosat, B. R. Bloom, A. M. Krensky, and R. L. Modlin, “Granulysin: a lethal weapon of cytolytic T cells,” Immunology Today, vol. 20, no. 9, pp. 390–394, 1999.
- S. V. Peña, D. A. Hanson, B. A. Carr, T. J. Goralski, and A. M. Krensky, “Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins,” The Journal of Immunology, vol. 158, no. 6, pp. 2680–2688, 1997.
- W. C. Manning, S. O'Farrell, T. J. Goralski, and A. M. Krensky, “Genomic structure and alternative splicing of 519, a gene expressed late after T cell activation,” The Journal of Immunology, vol. 148, no. 12, pp. 4036–4042, 1992.
- D. A. Hanson, A. A. Kaspar, F. R. Poulain, and A. M. Krensky, “Biosynthesis of granulysin, a novel cytolytic molecule,” Molecular Immunology, vol. 36, no. 7, pp. 413–422, 1999.
- J. Jongstra, T. J. Schall, and B. J. Dyer, “The isolation and sequence of a novel gene from a human functional T cell line,” The Journal of Experimental Medicine, vol. 165, no. 3, pp. 601–614, 1987.
- L. Mincheva-Nilsson, O. Nagaeva, K. G. Sundqvist, M. L. Hammarström, S. Hammarström, and V. Baranov, “γδ T cells of human early pregnancy decidua: evidence for cytotoxic potency,” International Immunology, vol. 12, no. 5, pp. 585–596, 2000.
- F. M. Spada, E. P. Grant, P. J. Peters et al., “Self-recognition of CD1 by γ/δ T cells: implications for innate immunity,” The Journal of Experimental Medicine, vol. 191, no. 6, pp. 937–948, 2000.
- F. Dieli, M. Troye-Blomberg, J. Ivanyi et al., “Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by V-γ9/Vδ2 T lymphocytes,” Journal of Infectious Diseases, vol. 184, no. 8, pp. 1082–1085, 2001.
- J. L. Gansert, V. Kießler, M. Engele et al., “Human NKT cells express granulysin and exhibit antimycobacterial activity,” The Journal of Immunology, vol. 170, no. 6, pp. 3154–3161, 2003.
- R. S. Munford, P. O. Sheppard, and P. J. O'Hara, “Saposin-like proteins (SAPLIP) carry out diverse functions on a common backbone structure,” Journal of Lipid Research, vol. 36, no. 8, pp. 1653–1663, 1995.
- D. H. Anderson, M. R. Sawaya, D. Cascio et al., “Granulysin crystal structure and a structure-derived lytic mechanism,” Journal of Molecular Biology, vol. 325, no. 2, pp. 355–365, 2003.
- M. Andersson, H. Gunne, B. Agerberth et al., “NK-lysin, a novel effector peptide of cytotoxic T and NK cells. Structure and cDNA cloning of the porcine form, induction by interleukin 2, antibacterial and antitumour activity,” The EMBO Journal, vol. 14, no. 8, pp. 1615–1625, 1995.
- J. J. Endsley, J. L. Furrer, M. A. Endsley et al., “Characterization of bovine homologues of granulysin and NK-lysin,” The Journal of Immunology, vol. 173, no. 4, pp. 2607–2614, 2004.
- E. G. Davis, Y. Sang, B. Rush, G. Zhang, and F. Blecha, “Molecular cloning and characterization of equine NK-lysin,” Veterinary Immunology and Immunopathology, vol. 105, no. 1-2, pp. 163–169, 2005.
- J. W. Heusel, R. L. Wesselschmidt, S. Shresta, J. H. Russell, and T. J. Ley, “Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells,” Cell, vol. 76, no. 6, pp. 977–987, 1994.
- S. Gamen, D. A. Hanson, A. Kaspar, J. Naval, A. M. Krensky, and A. Anel, “Granulysin-induced apoptosis. I. Involvement of at least two distinct pathways,” The Journal of Immunology, vol. 161, no. 4, pp. 1758–1764, 1998.
- A. A. Kaspar, S. Okada, J. Kumar et al., “A distinct pathway of cell-mediated apoptosis initiated by Granulysin,” The Journal of Immunology, vol. 167, no. 1, pp. 350–356, 2001.
- J. Pardo, P. Pérez-Galán, S. Gamen et al., “A role of the mitochondrial apoptosis-inducing factor in granulysin-induced apoptosis,” The Journal of Immunology, vol. 167, no. 3, pp. 1222–1229, 2001.
- S. Okada, Q. Li, J. C. Whitin, C. Clayberger, and A. M. Krensky, “Intracellular mediators of granulysin-induced cell death,” The Journal of Immunology, vol. 171, no. 5, pp. 2556–2562, 2003.
- F. A. X. Schanne, A. B. Kane, E. E. Young, and F. L. Farber, “Calcium dependence of toxic cell death: a final common pathway,” Science, vol. 206, no. 4419, pp. 700–702, 1979.
- I. Vermes, C. Haanen, H. Steffens-Nakken, and C. Reutelingsperger, “A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V,” Journal of Immunological Methods, vol. 184, no. 1, pp. 39–51, 1995.
- H. Repp, H. Nieper, H. J. Draheim, A. Koschinski, H. Müller, and F. Dreyer, “Infectious bursal disease virus changes the potassium current properties of chicken embryo fibroblasts,” Virology, vol. 246, no. 2, pp. 362–369, 1998.
- F. M. Hughes Jr. and J. A. Cidlowski, “Potassium is a critical regulator of apoptotic enzymes in vitro and in vivo,” Advances in Enzyme Regulation, vol. 39, pp. 157–171, 1999.
- M. Barry and R. C. Bleackley, “Cytotoxic T lymphocytes: all roads lead to death,” Nature Reviews Immunology, vol. 2, no. 6, pp. 401–409, 2002.
- K. M. Edwards, C. M. Kam, J. C. Powers, and J. A. Trapani, “The human cytotoxic T cell granule serine protease granzyme H has chymotrypsin-like (chymase) activity and is taken up into cytoplasmic vesicles reminiscent of granzyme B-containing endosomes,” Journal of Biological Chemistry, vol. 274, no. 43, pp. 30468–30473, 1999.
- C. J. Froelich, K. Orth, J. Turbov et al., “New paradigm for lymphocyte granule-mediated cytotoxicity: target cells bind and internalize granzyme B, but an endosomolytic agent is necessary for cytosolic delivery and subsequent apoptosis,” Journal of Biological Chemistry, vol. 271, no. 46, pp. 29073–29079, 1996.
- D. A. Jans, L. J. Briggs, P. Jans et al., “Nuclear targeting of the serine protease granzyme A (fragmentin-1),” Journal of Cell Science, vol. 111, no. 17, pp. 2645–2654, 1998.
- M. J. Pinkoski, M. Hobman, J. A. Heibein et al., “Entry and trafficking of granzyme B in target cells during granzyme B-perforin-mediated apoptosis,” Blood, vol. 92, no. 3, pp. 1044–1054, 1998.
- L. Shi, S. Mai, S. Israels, K. Browne, J. A. Trapani, and A. H. Greenberg, “Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization,” The Journal of Experimental Medicine, vol. 185, no. 5, pp. 855–866, 1997.
- D. H. Canaday, R. J. Wilkinson, Q. Li, C. V. Harding, R. F. Silver, and W. H. Boom, “CD4+ and CD8+ T cells kill intracellular Mycobacterium tuberculosis by a perforin and Fas/Fas ligand-independent mechanism,” The Journal of Immunology, vol. 167, no. 5, pp. 2734–2742, 2001.
- R. V. Saini, C. Wilson, M. W. Finn, T. Wang, A. M. Krensky, and C. Clayberger, “Granulysin delivered by cytotoxic cells damages endoplasmic reticulum and activates caspase-7 in target cells,” The Journal of Immunology, vol. 186, no. 6, pp. 3497–3504, 2011.
- Z. Wang, E. Choice, A. Kaspar et al., “Bactericidal and tumoricidal activities of synthetic peptides derived from granulysin,” The Journal of Immunology, vol. 165, no. 3, pp. 1486–1490, 2000.
- W. H. Chung, S. I. Hung, J. Y. Yang et al., “Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis,” Nature Medicine, vol. 14, no. 12, pp. 1343–1350, 2008.
- A. Deng, S. Chen, Q. Li, S. C. Lyu, C. Clayberger, and A. M. Krensky, “Granulysin, a cytolytic molecule, is also a chemoattractant and proinflammatory activator,” The Journal of Immunology, vol. 174, no. 9, pp. 5243–5248, 2005.
- P. Tewary, D. Yang, G. De La Rosa et al., “Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin,” Blood, vol. 116, no. 18, pp. 3465–3474, 2010.
- C. J. Turtle and D. N. J. Hart, “Dendritic cell biology and application for tumour immunotherapy,” Cancer Forum, vol. 26, no. 2, pp. 109–112, 2002.
- J. A. López and D. N. J. Hart, “Current issues in dendritic cell cancer immunotherapy,” Current Opinion in Molecular Therapeutics, vol. 4, no. 1, pp. 54–63, 2002.
- L. P. Huang, S. C. Lyu, C. Clayberger, and A. M. Krensky, “Granulysin-mediated tumor rejection in transgenic mice,” The Journal of Immunology, vol. 178, no. 1, pp. 77–84, 2007.
- H. Ohtani, “Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human colorectal cancer.,” Cancer Immunity, vol. 7, p. 4, 2007.
- F. Pagès, A. Berger, M. Camus et al., “Effector memory T cells, early metastasis, and survival in colorectal cancer,” The New England Journal of Medicine, vol. 353, no. 25, pp. 2654–2666, 2005.
- A. Kishi, Y. Takamori, K. Ogawa et al., “Differential expression of granulysin and perforin by NK cells in cancer patients and correlation of impaired granulysin expression with progression of cancer,” Cancer Immunology, Immunotherapy, vol. 50, no. 11, pp. 604–614, 2001.
- S. Saigusa, T. Ichikura, H. Tsujimoto et al., “Serum granulysin level as a novel prognostic marker in patients with gastric carcinoma,” Journal of Gastroenterology and Hepatology, vol. 22, no. 8, pp. 1322–1327, 2007.
- M. Sekiya, A. Ohwada, M. Katae, T. Dambara, I. Nagaoka, and Y. Fukuchi, “Adenovirus vector-mediated transfer of 9 kDa granulysin induces DNA fragmentation in HuD antigen-expressing small cell lung cancer murine model cells,” Respirology, vol. 7, no. 1, pp. 29–35, 2002.
- Z. Yi, Y. Fu, G. Jin, M. Li, X. Zhang, and W. Song, “Intracellularly expressed granulysin induced apoptosis in hepatoma cells and role of mitochondrial apoptotic pathway,” Cellular Immunology, vol. 255, no. 1-2, pp. 76–81, 2009.