Evaluation of Acute Locoregional Toxicity in Patients with Breast Cancer Treated with Adjuvant Radiotherapy in Combination with Pazopanib

Table 2

Acute locoregional toxicity of concurrent Pazopanib + RT versus RT alone scored using CTCAE.

Locoregional; toxicity	Pazopanib + RT		RT Alone
	Grade 1-2	Grade 3–5	Grade 1-2	Grade 3–5
	n affected (total)	n affected (total)	n affected (total)	n affected (total)
Fatigue	12 (12)	0 (12)	25 (25)	0 (25)
Dermatitis radiation	12 (12)	0 (12)	21 (19)	4 (25)
Skin hyperpigmentation	2 (12)	0 (12)	15 (25)	0 (25)
Skin ulceration	1 (12)	0 (12)	0 (25)	0 (25)
Soft tissue fibrosis	0 (12)	0 (12)	0 (25)	0 (25)
Pneumonitis	0 (12)	0 (12)	0 (25)	0 (25)
Diarrhea	3 (12)	0 (12)	0 (25)	0 (25)
Hypertension	1 (12)	0 (12)	0 (25)	0 (25)
Nausea	2 (12)	0 (12)	0 (25)	0 (25)
Anorexia	1 (12)	1 (12)	0 (25)	0 (25)

RT: radiotherapy; CTCAE: Common Terminology Criteria for Adverse Events (v4.0).