Research Article

Comparison of Gene Expression Profiling in Sarcomas and Mesenchymal Stem Cells Identifies Tumorigenic Pathways in Chemically Induced Rat Sarcoma Model

Table 1

Pathways with higher incidence of strongly expressed genes.

Rat MSCs P  value

Cell adhesion<0.0001
ECM-receptor interaction<0.0001
Cytokine-cytokine-receptor interaction<0.0001
Chemokine signaling<0.0001
Jak-STAT signaling= 0.0004
Wnt signaling= 0.0224

Rat Sarcomas P  value

DNA replication<0.0001
Cell cycle= 0.0005
Mismatch repair= 0.0020
Hedgehog signaling= 0.0064