- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Volume 2012 (2012), Article ID 910905, 5 pages
Steroid-Induced Diabetes: Is It Just Unmasking of Type 2 Diabetes?
1Department of Endocrinology, Diabetes Centre, Royal Prince Alfred Hospital, Level 6, West Wing, Camperdown, NSW 2050, Australia
2Sydney Medical School, The University of Sydney, D06, Sydney, NSW 2006, Australia
Received 6 March 2012; Accepted 29 April 2012
Academic Editors: G. Garruti and G. F. Wagner
Copyright © 2012 Lisa R. Simmons et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Aims. We compared the demographic profile and clinical characteristics of individuals with new onset steroid-induced diabetes (NOSID) to Type 2 diabetes (T2DM) patients with and without steroid treatment. Methods. The demographic profile and clinical characteristics of 60 individuals who developed NOSID were examined and matched to 60 type 2 diabetes patients receiving steroid therapy (T2DM+S) and 360 diabetic patients not on steroids (T2DM) for age, duration of diabetes, HbA1c, gender, and ethnicity. Results. Patients who developed NOSID had less family history of diabetes () and were less overweight (). NOSID was more commonly treated with insulin. Despite a matching duration of diabetes and glycaemic control, significantly less retinopathy was found in the group of patients with NOSID (). Conclusions. It appears that steroid treatment primarily precipitated diabetes in a group of individuals otherwise less affected by risk factors of diabetes at that point in time, rather than just opportunistically unmasking preexisting diabetes. Furthermore, the absence of retinopathy suggests that patients with NOSID had not been exposed to long periods of hyperglycaemia. However, the impact of the underlying conditions necessitating steroid treatment and concomitant medications such as immunosuppressants on diabetes development remain to be defined.
Glucocorticoids are commonly used to treat a wide variety of both acute and chronic illnesses. Their use can be accompanied by a multitude of side effects, including hyperglycaemia and can worsen preexisting diabetes or precipitate new “steroid-induced” diabetes [1–5].The term “steroid diabetes” was coined by Ingle in the 1940s to describe the hyperglycaemia noted in rats receiving glucocorticoids [6–8]. Similarly, glucocorticoid-induced hyperglycaemia has long been noted in humans [9–11]. Steroids elevate blood glucose levels by increasing hepatic glucose production and inhibiting glucose uptake into muscles. They also have a complex effect on beta cell function [9–11]. Yet, the pathophysiology of glucocorticoid-induced diabetes and the relative contributions of both β-cell dysfunction and insulin resistance are still to be elucidated [4, 5, 7, 12]. In addition, the clinical course and optimal treatment of New-Onset Steroid Induced Diabetes (NOSID) still remain unclear.
Hyperglycaemia can be one of the troubling consequences of both short- and long-term steroid use. NOSID has been identified in between 1.5% and 47% of patients. Variability of this incidence is thought to be due to differences in patient population, treatment protocols, and the definition of diabetes [13–16]. Despite being well established that steroids have a pronounced hyperglycaemic effect , the risk factors and impact of developing NOSID are poorly characterised or quantified. Review of the literature suggests that increasing dose, duration of therapy, ethnicity, age, underlying disease, and BMI may be risk factors for the induction of NOSID [18–22]. Studies of renal transplant recipients have shown that the incidence of NOSID increases with steroid dose and is often first detected after increasing the steroid dose during episodes of rejection . The association of traditional risk factors such as obesity and family history with the development of hyperglycaemia remains unclear [24–28]. The impact of NOSID on diabetic complications has also not been well characterized.
The aim of our study is to examine the demographic profile and clinical characteristics of patients who develop NOSID. We compared the profile of individuals with NOSID to type 2 diabetes (T2DM) patients with and without steroid treatment in an attempt to determine their similarities and differences, both in diabetogenic risk factors and diabetic complications.
2. Materials and Methods
Data from individuals attending the Royal Prince Alfred Hospital Diabetes Centre in Sydney during a 10-year period were collected and made available for review. NOSID was defined as diabetes diagnosed for the first time during steroid therapy. The criteria used were more than one random BGL >11 mmol/L or more than one fasting BGL >7.0 mmol/L following the initiation of steroid therapy . Each patient was assessed for the presence of diabetic complications using a standardised protocol described previously . Information collected at these visits includes demographic details, past medical history, weight, HbA1c, albuminuria, blood pressure, and fasting lipids. Nephropathy was evaluated by way of creatinine and the urine albumin to creatinine ratio. Measurement of vibration perception threshold by biothesiometer, sensation via monofilament, and ankle reflexes allowed evaluation for signs of neuropathy. In addition, retinopathy was assessed by direct fundoscopy through dilated pupils or via a report from the individual’s treating ophthalmologist.
Complete complications assessment data were available for a total of 60 patients with NOSID. Data from these individuals were compared with complications assessment data for patients with type 2 diabetes as well as those with type 2 diabetes receiving steroids at the time of complications assessment. Patients with NOSID were matched 1 : 1 with patients known to have type 2 diabetes receiving steroid therapy (T2DM+S) and 1 : 6 with those not on steroids (T2DM). Matching criteria included age, gender, ethnicity, duration of diabetes, and HbA1c. A total of 480 patients were studied made up of 60 individuals diagnosed with NOSID, 60 type 2 diabetics receiving steroid therapy, and 360 patients with type 2 diabetes not on steroids.
The metabolic syndrome was defined as a score of 3 or greater according to the World Health Organization 1999 criteria [31, 32]. As all participants fulfilled the criteria for hyperglycaemia, at least two of remaining criteria were required.
Data were analysed using NCSS (Number Cruncher Statistical System, Kaysville, UT) 2007. Data were grouped into three groups: (1) new-onset steroid-induced diabetes, (2) type 2 diabetes on steroids, and (3) type 2 diabetes. Optimal data matching procedures were used to match the three groups. Potential bias was avoided by matching the patients for confounders that may influence complications status. The data were then matched by age, duration of diabetes, HbA1c, ethnicity, and gender. A propensity score was calculated for the matching procedure using logistic regression, all confounders were included in the model. Mahalanobis Distance within Propensity Score Calipers (no matches outside calipers) were used to calculate the distance between the three groups. Patients were matched 1 : 1 with type 2 diabetics receiving steroid therapy and 1 : 6 with type 2 diabetics not on steroids. Continuous data were checked for normality and presented as mean and standard deviation or median and interquartile range. ANOVA was used to compare means or medians of the three groups. Bonferroni or Kruskal-Wallis adjustments were performed between the three groups to adjust for multiple groups. Categorical data was presented as percentage. Chi-square and Fisher’s exact tests were used to compare the groups. Statistical significance was accepted at .
A total of 271 individuals with NOSID attended the Diabetes Centre for assessment and treatment. Patients were treated with oral steroids at a dose which ranged between 5 mg and 40 mg daily. Sixty of these individuals with complete demographic data and complications assessment were included in this study and had their data analysed. The most common reason for requiring steroid therapy and thus needing review at our Diabetes Centre was posttransplant immunosuppression (75%). Other conditions included respiratory, renal and rheumatological disease (25%). The demographic and clinical profiles of study patients are shown in Table 1.
Those individuals who developed NOSID were noted to have less family history of diabetes when compared with patients with Type 2 diabetes receiving steroid therapy and type 2 diabetes alone (). Patients who developed NOSID weighed less () than those with known type 2 diabetes, despite the steroid therapy which is known to cause weight gain. There was, however, no significant difference () in the prevalence of metabolic syndrome between the three groups.
Overall, NOSID was more commonly treated with insulin ().
Despite a matching duration of diabetes, significantly less retinopathy was found in the group of patients with NOSID (). Interestingly, none of the patients who developed NOSID were found to have retinopathy.
Macrovascular complications were significantly lower () in the NOSID group when compared with type 2 diabetics receiving steroid therapy. This may be due to the fact that patients with type 2 diabetes also receiving steroids were likely to be more unwell and have more active comorbidities than those patients on steroids alone. Although a difference exists between the patients with NOSID and those known to have type 2 diabetes alone, this result does not reach statistical significance ().
Steroids exert a variety of changes that lead to hyperglycaemia or exacerbate preexisting diabetes. The causative mechanisms of hyperglycaemia are multifactorial and so too are the clinical characteristics and demographics of individuals likely to develop NOSID [13, 17, 24–28, 33].
It is known that being overweight is often associated with impaired glucose tolerance and increased risk of developing type 2 diabetes [21, 34, 35]. This study shows that the group of patients who developed diabetes following steroid therapy not only weighed less, when compared to individuals with type 2 diabetes receiving or not receiving steroids, but that despite treatment with steroids, which in itself may cause weight gain, obesity was not a distinctive feature. Furthermore, type 2 diabetes is typically associated with a strong family history [36–39]. By contrast, patients with NOSID in this study had less family history of diabetes. If NOSID was simply type 2 diabetes uncovered opportunistically (due to concurrent illness or steroid treatment), a similar prevalence of family history and obesity would be expected in all groups. These two findings are more consistent with the notion that patients with NOSID have less risk factors for diabetes. They only become diabetic under the stress of steroid treatment.
In our cohort of patients who developed steroid-induced diabetes, none of the individuals developed diabetic retinopathy despite the same duration of disease and HbA1c as patients with known type 2 diabetes. As duration of chronic hyperglycaemia is the fundamental prerequisite for diabetic retinopathy in patients with both type 1 and type 2 diabetes [40–47], the individuals with NOSID are likely not to be hyperglycaemic sufficiently long enough to develop end-organ damage [46–52]. The early detection and intensive glycaemic control in this cohort of patients may have prevented or delayed the onset and progression of diabetic retinopathy. Our observation has practical clinical significance. If a patient with NOSID has no diabetic retinopathy at the time of diagnosis, routine screening for this microvascular complication is not a high priority for the first few years. In view of the high and increasing demand for diabetes services, this would help to prioritise treatment.
The underlying disease for which steroid therapy is instituted is often inflammatory or cytokine mediated which may in its own right affect a patient’s glycaemic control. Furthermore, a large proportion of our study population was receiving steroid therapy after transplantation. The impact of steroid use in these individuals is confounded by the use of calcineurin inhibitors (particularly tacrolimus) and sirolimus which contribute to the risk of glucose intolerance possibly by suppressing insulin production [13–16, 23–26]. Additional confounding variables that may affect the incidence and cause of steroid-induced diabetes in the cohort who underwent organ transplantation include the transplant itself, hepatitis C virus status befor transplant, and the patient’s weight prior to transplantation [13, 18, 26]. In addition, in patients undergoing renal transplantation, pretransplant diabetes may be masked by diminished insulin metabolism associated with kidney dysfunction [13, 25, 26]. The influence of these factors require further investigation.
Our study was based on a modest sample size; however the subjects in all three groups were well matched for age, duration of diabetes, HbA1c, gender, and ethnicity. Although, retrospective in analysis, the data on clinical parameters and complications was collected prospectively in the same way for all three groups, according to a standardised clinical protocol . A long-term prospective study to confirm the risk factors, demographic profile, and clinical characteristics that predispose individuals to developing steroid-induced hyperglycaemia will provide further insight into the underlying characteristics and profile of individuals more susceptible to NOSID.
- G. Pagano, P. Cavallo-Perin, M. Cassader, et al., “An in vivo and in vitro study of the mechanism of prednisone-induced insulin resistance in healthy subjects,” Journal of Clinical Investigation, vol. 72, no. 5, pp. 1814–1820, 1983.
- D. L. Trence, “Management of patients on chronic glucocorticoid therapy: an endocrine perspective,” Primary Care, vol. 30, no. 3, pp. 593–605, 2003.
- S. S. Braithewaite, W. G. Barr, and J. D. Thomas, “Diabetes management during glucocorticoid therapy for nonendocrine disease,” Endocrine Practice, vol. 2, no. 5, pp. 320–325, 1996.
- M. B. Miller and J. Neilson, “Clinical features of the diabetic syndrome appearing after steroid therapy,” Postgraduate Medical Journal, vol. 40, no. 469, pp. 660–669, 1964.
- I. B. Hirsch and D. S. Paauw, “Diabetes management in special situations,” Endocrinology and Metabolism Clinics of North America, vol. 26, no. 3, pp. 631–645, 1997.
- D. J. Ingle, “The production of glycosuria in the normal rat by means of 17-hydroxy-dehydroxycorticosterone,” Endocrinology, vol. 29, pp. 649–657, 1941.
- D. J. Ingle, D. F. Beary, and A. Purmalis, “Some further observations on steroid diabetes in the rat,” Acta endocrinologica, vol. 15, no. 2, pp. 129–132, 1954.
- D. J. Ingle, H. A. Winter, C. H. Li, and H. M. Evans, “Production of glycosuria in normal rats by means of adrenocorticotrophic hormone,” Science, vol. 101, no. 2635, pp. 671–672, 1945.
- M. Hollingdal, C. B. Juhl, R. Dall et al., “Glucocorticoid induced insulin resistance impairs basal but not glucose entrained high-frequency insulin pulsatility in humans,” Diabetologia, vol. 45, no. 1, pp. 49–55, 2002.
- C. Lambillotte, P. Gilon, and J. C. Henquin, “Direct glucocorticoid inhibition of insulin secretion: an in vitro study of dexamethasone effects in mouse islets,” Journal of Clinical Investigation, vol. 99, no. 3, pp. 414–423, 1997.
- S. Clement, S. S. Braithwaite, and M. F. Magee, “Management of diabetes and hyperglycemia in hospitals,” Diabetes Care, vol. 27, no. 2, pp. 553–591, 2004.
- J. J. Bookman, S. R. Drachman, L. E. Schaefer, and D. Adlersberg, “Steroid diabetes in man; the development of diabetes during treatment with cortisone and corticotropin,” Diabetes, vol. 2, no. 2, pp. 100–111, 1953.
- T. G. Valderhaug, J. Hjelmesæth, H. Rollag et al., “Reduced incidence of new-onset posttransplantation diabetes mellitus during the last decade,” Transplantation, vol. 84, no. 9, pp. 1125–1130, 2007.
- R. D. Bloom and M. F. Crutchlow, “New-onset diabetes mellitus in the kidney recipient: diagnosis and management strategies,” Clinical Journal of the American Society of Nephrology, vol. 3, supplement 2, pp. S38–S48, 2008.
- P. Marchetti, “New-onset diabetes after liver transplantation: from pathogenesis to management,” Liver Transplantation, vol. 11, no. 6, pp. 612–620, 2005.
- R. Giannarelli, A. Coppelli, U. Boggi et al., “New-onset diabetes after kidney transplantation,” Diabetic Medicine, vol. 22, no. 8, pp. 1125–1126, 2005.
- B. Hoogwerf and R. D. Danese, “Drug selection and the management of corticosteroid-related diabetes mellitus,” Rheumatic Disease Clinics of North America, vol. 25, no. 3, pp. 489–505, 1999.
- S. Chadban, “New-onset diabetes after transplantation—should it be a factor in choosing an immunosuppressant regimen for kidney transplant recipients,” Nephrology Dialysis Transplantation, vol. 23, no. 6, pp. 1816–1818, 2008.
- J. N. Clore and L. Thurby-Hay, “Glucocorticoid-induced hyperglycemia,” Endocrine Practice, vol. 15, no. 5, pp. 469–474, 2009.
- C. S. Levetan and M. F. Magee, “Hospital management of diabetes,” Endocrinology and Metabolism Clinics of North America, vol. 29, no. 4, pp. 745–770, 2000.
- C. R. Ariza-Andraca, L. A. Barile-Fabris, A. C. Frati-Munari, and P. Baltazar-Montufar, “Risk factors for steroid diabetes in rheumatic patients,” Archives of Medical Research, vol. 29, no. 3, pp. 259–262, 1998.
- T. Iwamoto, Y. Kagawa, Y. Naito, S. Kuzuhara, and M. Kojima, “Steroid-induced diabetes mellitus and related risk factors in patients with neurologic diseases,” Pharmacotherapy, vol. 24, no. 4, pp. 508–514, 2004.
- P. Arner, R. Gunnarsson, S. Blomdahl, and C. G. Groth, “Some characteristics of steroid diabetes: a study in renal-transplant recipients receiving high-dose corticosteroid therapy,” Diabetes Care, vol. 6, no. 1, pp. 23–25, 1983.
- D. Roth, M. Milgrom, V. Esquenazi, L. Fuller, G. Burke, and J. Miller, “Posttransplant hyperglycemia. Increased incidence in cyclosporine-treated renal allograft recipients,” Transplantation, vol. 47, no. 2, pp. 278–281, 1989.
- N. B. Sumrani, V. Delaney, Z. K. Ding et al., “Diabetes mellitus after renal transplantation in the cyclosporine era—an analysis of risk factors,” Transplantation, vol. 51, no. 2, pp. 343–347, 1991.
- L. Vesco, M. Busson, J. Bedrossian, M. O. Bitker, C. Hiesse, and P. Lang, “Diabetes mellitus after renal transplantation: characteristics, outcome, and risk factors,” Transplantation, vol. 61, no. 10, pp. 1475–1478, 1996.
- J. H. Gurwitz, R. L. Bohn, R. J. Glynn, M. Monane, H. Mogun, and J. Avorn, “Glucocorticoids and the risk for initiation of hypoglycemic therapy,” Archives of Internal Medicine, vol. 154, no. 1, pp. 97–101, 1994.
- W. Kern, E. F. Stange, H. L. Fehm, and H. H. Klein, “Glucocorticoid-induced diabetes mellitus in gastrointestinal diseases,” Zeitschrift fur Gastroenterologie, supplement 1, pp. 36–42, 1999.
- American Diabetes Association, “Standards of medical care in diabetes—2009,” Diabetes Care, vol. 32, supplement 1, pp. S13–S61, 2009.
- M. L. McGill, D. K. Yue, and J. R. Turtle, “A single visit diabetes complication assessment service: a complement to diabetes management at the primary care level,” Diabetic Medicine, vol. 10, no. 4, pp. 366–370, 1993.
- K. G. Alberti and P. Z. Zimmet, “Definition, diagnosis and classification of diabetes mellitus and its complications, part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation,” Diabetic Medicine, vol. 15, no. 7, pp. 539–533, 1998.
- G. Marchesini, G. Forlani, F. Cerrelli et al., “WHO and ATPIII proposals for the definition of the metabolic syndrome in patients with Type 2 diabetes,” Diabetic Medicine, vol. 21, no. 4, pp. 383–387, 2004.
- D. L. Trence and I. B. Hirsch, “Hyperglycemic crises in diabetes mellitus type 2,” Endocrinology and Metabolism Clinics of North America, vol. 30, no. 4, pp. 817–831, 2001.
- A. J. Cameron, D. W. Dunstan, N. Owen et al., “Health and mortality consequences of abdominal obesity: evidence from the AusDiab study,” Medical Journal of Australia, vol. 191, no. 4, pp. 202–208, 2009.
- A. J. Cameron and P. Z. Zimmet, “Expanding evidence for the multiple dangers of epidemic abdominal obesity,” Circulation, vol. 117, no. 13, pp. 1624–1626, 2008.
- Y. Sung, J. Y. Oh, N. H. Kyung, and Y. J. Jang, “Impaired insulin secretion in subjects with impaired glucose tolerance; role of family history of type 2 diabetes,” Diabetes Research and Clinical Practice, vol. 50, supplement 1, p. 103, 2000.
- J. N. Wei, H. Y. Li, Y. C. Wang et al., “Detailed family history of diabetes identified children at risk of type 2 diabetes: a population-based case-control study,” Pediatric Diabetes, vol. 11, no. 4, pp. 258–264, 2010.
- Y. Chen, D. C. Rennie, and J. A. Dosman, “Synergy of BMI and family history on diabetes: the humboldt study,” Public Health Nutrition, vol. 13, no. 4, pp. 461–465, 2010.
- S. Hariri, P. W. Yoon, R. Moonesinghe, R. Valdez, and M. J. Khoury, “Evaluation of family history as a risk factor and screening tool for detecting undiagnosed diabetes in a nationally representative survey population,” Genetics in Medicine, vol. 8, no. 12, pp. 752–759, 2006.
- The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group, “Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy,” The New England Journal of Medicine, vol. 342, no. 6, pp. 381–389, 2000.
- E. M. Kohner, “Microvascular disease: what does the UKPDS tell us about diabetic retinopathy?” Diabetic Medicine, vol. 25, supplement 2, pp. 20–24, 2008.
- S. Genuth, “The UKPDS and its global impact,” Diabetic Medicine, vol. 25, supplement 2, pp. 57–62, 2008.
- R. N. Frank, “Diabetic retinopathy,” The New England Journal of Medicine, vol. 350, no. 1, pp. 48–58, 2004.
- Q. Mohamed, M. C. Gillies, and T. Y. Wong, “Management of diabetic retinopathy: a systematic review,” Journal of the American Medical Association, vol. 298, no. 8, pp. 902–916, 2007.
- D. S. Fong, L. P. Aiello, F. L. Ferris III, and R. Klein, “Diabetic retinopathy,” Diabetes Care, vol. 27, no. 10, pp. 2540–2553, 2004.
- R. Klein, B. E. Klein, S. E. Moss, M. D. Davis, and D. L. DeMets, “The wisconsin epidemiologic study of diabetic retinopathy. III. Prevalence and risk of diabetic retinopathy when age at diagnosis is 30 or more years,” Archives of Ophthalmology, vol. 102, no. 4, pp. 527–532, 1984.
- R. Klein, B. E. Klein, S. E. Moss, M. D. Davis, and D. L. DeMets, “The wisconsin epidemiologic study of diabetic retinopathy. II. Prevalence and risk of diabetic retinopathy when age at diagnosis is less than 30 years,” Archives of Ophthalmology, vol. 102, no. 4, pp. 520–526, 1984.
- UKPDS Study Group, “Complications in newly diagnosed type 2 diabetic patients and their association with different clinical and biochemical risk factors. UKPDS Study 6,” Diabetes Research, vol. 13, no. 1, pp. 1–11, 1990.
- Y. Ohkubo, H. Kishikawa, E. Araki et al., “Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study,” Diabetes Research and Clinical Practice, vol. 28, no. 2, pp. 103–117, 1995.
- UK Prospective Diabetes Study Group, “Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33),” The Lancet, vol. 352, no. 9131, pp. 837–853, 1998.
- H. A. Keenan, T. Costacou, J. K. Sun et al., “Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: the 50-year medalist study,” Diabetes Care, vol. 30, no. 8, pp. 1995–1997, 2007.
- Diabetes Prevention Program Research Group, “The prevalence of retinopathy in impaired glucose tolerance and recent-onset diabetes in the diabetes prevention program,” Diabetic Medicine, vol. 24, no. 2, pp. 137–144, 2007.