Senescence-Accelerated Mice P8: A Tool to Study Brain Aging and Alzheimer's Disease in a Mouse Model

Table 1

Oxidative disturbances found in SAMP8.

Target	Modification	References
Protein carbonylation	Increased	[22–25]
Lipid peroxidation	Increased	[22, 24, 26–28]
Nucleic acid oxidation	Increased	[25, 29]
Mn SOD	Decreased activity	[30]
Glutathione reductase	Not modified or decreased activity	[22, 31]
Catalase	Not modified or decreased activity	[22, 31]
Glutamine synthetase	Decreased activity	[24]
NO synthase	Increased activity	[32–34]
Accumulation of 8-oxoguanine	Increased	[35]