Review Article
Senescence-Accelerated Mice P8: A Tool to Study Brain Aging and Alzheimer's Disease in a Mouse Model
Table 2
Histopathological and cellular markers of AD and aging found in SAMP8.
| Target | Modification | References |
| Tau protein | Increased levels and phosphorylation | [22, 55, 56] | Tau kinases | Increased levels or activity in Cdk5/p25 and GSK3 | [22, 58, 59] | Receptor for advanced glycation end product (RAGE) | Increased | [75] | APP protein | Increased | [63ā65, 80, 85, 86] | B-amyloid | Amyloid content increased and aggregates | [26, 61, 62, 69, 70, 74, 87] | Secretases | ADAM-10 and PS1 | [65, 80, 88] | BBH | Disrupted | [72, 73, 89] |
|
|