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ISRN Emergency Medicine
Volume 2012 (2012), Article ID 927678, 6 pages
http://dx.doi.org/10.5402/2012/927678
Research Article

The Effects of QuikClot Combat Gauze, Fluid Resuscitation, and Movement on Hemorrhage Control in a Porcine Model

1US Army Graduate Program in Anesthesia, TX 79920, USA
2Brooke Army Medical Center and Northeastern University, 360 Huntington Avenue, Boston, MA 02115-5000, USA

Received 26 September 2012; Accepted 31 October 2012

Academic Editors: P. Eisenburger, M. Pocar, and C.-C. Wu

Copyright © 2012 Don Johnson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The purpose of this study was to compare the effectiveness of QuikClot Combat Gauze (QCG) compared to a control group on hemorrhage control; the amount of crystalloid volume infusion on rebleeding; the effect of movement on hemorrhage. This was a prospective, experimental design. Swine were randomly assigned to either the QCG ( ) or the control group ( ). Investigators transected the femoral artery and vein in each swine. After one minute of uncontrolled hemorrhage, the hemostatic agent, QCG, was placed into the wound followed by standard wound packing. The control group underwent the same procedures but without a hemostatic agent. After five minutes of direct pressure, a standard pressure dressing was applied. After 30 minutes, dressings were removed, and the wound was observed for rebleeding for 5 minutes. If hemostasis occurred, 5 liters of crystalloid was given over 5 minutes, and the wound was observed for rebleeding for 5 additional minutes. If no bleeding occurred, the extremity on the side of the injury was moved. There were significant differences in the amount of hemorrhage ( ), the amount of fluid administration ( ), and the number of movements ( ) between the QCG and control.