The Role of the Immune System in Nevirapine-Induced Subclinical Liver Injury of a Rat Model

<table>Serum concentrations (mean ± SD) of IL-2 (a), IFN-<svg height="9.9375" id="M34" style="vertical-align:-2.34499pt" version="1.1" viewbox="0 0 8.0625 9.9375" width="8.0625" xmlns="http://www.w3.org/2000/svg">
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</svg>  (b), TNF-<svg height="7.1750002" id="M35" style="vertical-align:-0.1254pt" version="1.1" viewbox="0 0 8.9375 7.1750002" width="8.9375" xmlns="http://www.w3.org/2000/svg">
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</svg>  (c) and nevirapine (NVP), (d), in rats treated daily with NVP, but 24 hours after challenge with saline (S; S + NVP) or lipopolysaccharide (LPS; LPS + NVP) on days 7, 14 and 21 treatment. Note<sup>†</sup>: indicates that the values for the nevirapine-treated group (S + NVP) were significantly (<svg height="11.25" id="M36" style="vertical-align:-0.30096pt" version="1.1" viewbox="0 0 56.150002 11.25" width="56.150002" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
<tspan style="font-size: 12.50px; " x="22.930502" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="29.182001" y="0">.</tspan>
<tspan style="font-size: 12.50px; " x="32.307751" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="38.559254" y="0">5</tspan>
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</svg>) different from those of the LPS + NVP group.</table>

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fig4

Figure 4

Figure 4: The Role of the Immune System in Nevirapine-Induced Subclinical Liver Injury of a Rat Model 