Research Article
The Role of the Immune System in Nevirapine-Induced Subclinical Liver Injury of a Rat Model
Table 1
Average weights (mean ± SD) and liver function test of each of the four groups () in the acute phase, at 6 and 24 hours after dosing.
| Group () | Weight (g) | Liver function (units/L) | ALP | ALT | AST |
| Untreated | | | | | 0 hours | 392 ± 13 | 262.5 ± 11 | 67.8 ± 24 | 169.3 ± 107 | LPS + S | | | | | 6 hours | 302 ± 22 | 214.2 ± 32 | 83.2 ± 28 | 161.0 ± 23 | 24 hours | 286 ± 20 | 274.8 ± 35 | 30.4 ± 3 | 131.4 ± 57 | S + NVP | | | | | 6 hours | 372 ± 26 | 268.0 ± 49 | 53.2 ± 6 | 31.4 ± 65 | 24 hours | 367 ± 32 | 271.6 ± 38 | 67.2 ± 8 | 135.0 ± 28 | LPS + NVP | | | | | 6 hours | 379 ± 18 | 175.6 ± 32 | 61.0 ± 16 | 134.2 ± 57 | 24 hours | 385 ± 8 | 205.8 ± 24 | 31.0 ± 8 | 106.6 ± 20 |
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Key: NVP: nevirapine, LPS: lipopolysaccharide, S: saline, ALP: alkaline phosphatase, ALT: alanine aminotransferase, and AST: aspartate aminotransferase.
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