The Role of the Immune System in Nevirapine-Induced Subclinical Liver Injury of a Rat Model

Table 1

Average weights (mean ± SD) and liver function test of each of the four groups (𝑛=5) in the acute phase, at 6 and 24 hours after dosing.

Group (𝑛=5)	Weight (g)	Liver function (units/L)
		ALP	ALT	AST
Untreated
0 hours	392 ± 13	262.5 ± 11	67.8 ± 24	169.3 ± 107
LPS + S
6 hours	302 ± 22	214.2 ± 32	83.2 ± 28	161.0 ± 23
24 hours	286 ± 20	274.8 ± 35	30.4 ± 3	131.4 ± 57
S + NVP
6 hours	372 ± 26	268.0 ± 49	53.2 ± 6	31.4 ± 65
24 hours	367 ± 32	271.6 ± 38	67.2 ± 8	135.0 ± 28
LPS + NVP
6 hours	379 ± 18	175.6 ± 32	61.0 ± 16	134.2 ± 57
24 hours	385 ± 8	205.8 ± 24	31.0 ± 8	106.6 ± 20

Key: NVP: nevirapine, LPS: lipopolysaccharide, S: saline, ALP: alkaline phosphatase, ALT: alanine aminotransferase, and AST: aspartate aminotransferase.