Sterculic Oil, a Natural SCD1 Inhibitor, Improves Glucose Tolerance in Obese ob/ob Mice

Figure 5

Sterculic oil supplementation increases expression of GLUT1 and markers of inflammation in gonadal adipose tissue of obese ob/ob mice. Gene expression analysis was performed in the gonadal adipose tissue of wild-type (WT) and ob/ob (OB) mice receiving an AIN-93G diet (AIN) or a sterculic oil-supplemented diet (SO). Relative mRNA expression of select (a) metabolic and (b) inflammatory genes. Data are presented as means ± SE; 𝑛=6-7 per group. Data were analyzed by two-way ANOVA and significance for the effects of diet (d), genotype (g) or their interaction (d×g) set at 𝑃<0.05. When a significant interaction effect was found a Bonferroni multiple comparisons test was used to determine differences within groups. ^¥𝑃<0.05 OB AIN versus OB SO.

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