mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer

Figure 2

mTOR signaling pathway. PI3K: phosphatidylinositol-3-kinase; mTOR: mammalian target of rapamycin; mTORC1: mTOR complex 1; mTORC2: mTOR complex 2; Raptor: regulatory-associated protein of mTOR; Rictor: rapamycin-insensitive companion of mTOR; mSIN1: mammalian stress-activated protein kinase interacting protein; eIF4E: eukaryotic initiation factor 4E; 4EBP1: eIF4E -binding protein 1; S6K1: S6 kinase 1; PKCα: protein kinase Cα; SGK1: glucocorticoid-induced protein kinase 1.