Research Article

A Convenient, TiCl4/SnCl4-Mediated Synthesis of N-Phenyl or N-Aryl Benzamidines and N-Phenylpicolinamidines

Table 1

SnCl4/TiCl4 catalysed coupling of substituted anilines with benzonitrile.

Entry no.AminesAmidinesa (isolated yield %)M.P. °C (Lit.)
by TiCl4by SnCl4

3aAniline7571114–116 (116)
3b2-Cl-Aniline6567108–110
3c4-F-Aniline646386–88

aAll products were characterised by IR, NMR, and mass spectral data and in comparison with authentic samples.