Research Article

A Convenient, TiCl4/SnCl4-Mediated Synthesis of N-Phenyl or N-Aryl Benzamidines and N-Phenylpicolinamidines

Table 2

SnCl4/TiCl4 catalysed coupling of 2-aminopyridine with substituted benzonitriles.

Entry no.AminesNitrilesAmidinesa (isolated yield %)M.P.°C (Lit.)
RXRby TiCl4by SnCl4

3dHNH726196 (97-98)
3eHN3-Cl6368114–116
3fHN4-Cl6963162–164
3gHN4-Br7366152–154
3h4-BrNH6763102–104

aAll products were characterised by IR, NMR, and mass spectral data and in comparison with authentic samples.