Effect of Chemical Enhancers in Transdermal Permeation of Alfuzosin Hydrochloride

Table 3

Solubility of AH in different chemical enhancers and release rate of formulations through dialysis membrane.

Formulation code	Solubility^a (mg/mL)	ER^bsol	Release rate (μg/cm^2/hr^1/2)
Control	23.34±1.07	1	143.41±0.10
CA1	26.42±1.05	1.13	223.37±0.21
CA2	29.34±1.12	1.25	230.99±0.05
CA3	42.92±0.65	1.83	58.95±0.39
CA4	27.65±1.02	1.18	20.81±0.28
CA5	25.44±1.08	1.08	194.75±0.21
CA6	33.53±1.10	1.43	241.47±0.08
CA7	30.86±1.43	1.32	205.35±0.43
CA8	35.32±1.02	1.51	219.79±0.25
CA9	20.92±1.12	0.89	396.36±0.53
CA10	28.67±1.05	1.22	254.44±0.18
CA11	38.27±1.03	1.63	197.61±0.37
CA12	42.60±1.15	1.82	214.94±0.25
CA13	35.88±0.87	1.53	324.07±0.52
CA14	26.90±0.93	1.15	221.29±0.32
CA15	32.74±1.15	1.40	219.26±0.24
CA16	40.61±1.32	1.73	224.50±0.29

^aSolubility is the solubility of AH in the hydrogel solvent mixture at 25°C. ^bER_sol is enhancement ratio of AH solubility over control solubility. Values represent mean ± S.D (𝑛=3).