Effect of Chemical Enhancers in Transdermal Permeation of Alfuzosin Hydrochloride

Table 4

Permeation parameters of AH formulations.

Formulation; code	𝑄24 (μg/cm^2)	Flux (μg/cm^2/hr)	Permeability coefficient; (×10^−03) (cm/hr)	Lag time (hr)	Skin content (μg/gm)	ER
Control	182.84±7.81	7.59±0.27	1.51±0.05	2.96±0.35	1246.79±10.63	1
CA1	274.17±6.17	11.91±0.16	2.38±0.03	1.06±0.15	981.20±05.65	1.51
CA2	365.05±4.78	16.16±0.22	3.23±0.04	2.26±0.15	754.61±16.47	2.05
CA3	307.43±6.40	14.24±0.19	2.84±0.03	2.70±0.20	342.33±05.30	1.80
CA4	257.73±6.02	12.56±0.19	2.51±0.03	2.33±0.15	1032.36±07.93	1.59
CA5	267.59±6.66	12.51±0.19	2.50±0.03	1.76±0.15	1133.28±11.33	1.58
CA6	589.89±5.05	25.34±0.09	5.06±0.01	0.76±0.15	955.63±09.41	3.21
CA7	383.55±7.03	17.08±0.21	3.41±0.04	0.80±0.10	676.34±09.68	2.16
CA8	566.02±4.71	25.88±0.08	5.17±0.01	1.10±0.20	567.82±11.96	3.28
CA9	518.65±6.69	22.39±0.20	4.47±0.04	1.23±0.15	713.82±12.33	2.84
CA10	702.74±7.49	30.38±0.18	6.07±0.03	0.30±0.20	592.20±08.54	3.85
CA11	507.26±6.73	22.67±0.18	4.53±0.03	0.46±0.15	651.33±09.00	2.87
CA12	702.28±6.97	31.08±0.21	6.21±0.04	0.13±0.05	355.93±08.60	3.94
CA13	351.39±6.95	14.87±0.14	2.97±0.02	0.50±0.10	877.00±08.28	1.88
CA14	303.85±6.08	12.99±0.15	2.59±0.03	0.83±0.15	561.93±09.26	1.64
CA15	314.25±4.80	14.79±0.09	2.95±0.01	1.33±0.15	875.97±08.61	1.87
CA16	490.75±6.04	21.38±0.08	4.27±0.01	0.43±0.15	687.58±08.30	2.71

𝑄₂₄ is the cumulative amount permeated in 24 hrs; ER is an enhancement ratio of the flux of chemical enhancers over control. Values represent mean ± S.D (𝑛=3).