Research Article

Inhibitory Effects of Trehalose on Malignant Melanoma Cell Growth: Implications for a Novel Topical Anticancer Agent on the Ocular Surface

Figure 9

Relationships between the factors in the G2 phase cell cycle. As indicated by the blue arrows, both increases (ATM, p53, Chk2, p21, p-cdc25) and decreases (cdc25 and cdc2/cyclin B1) of factors lead to the arrest of the G2/M cell cycle (blue arrows). After treatment with trealose, an increase was seen in the ATM, p53, Chk2, and p-cdc25 factors (red arrows). These results suggest the possibility that administration of trehalose leads to the G2/M cell cycle arrest and to apoptosis.
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