The Effects of Continuous Blood Purification for SIRS/MODS Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Table 6

TNF-α change.

Study or subgroup	CVVH			Control				Std. mean difference	Std. mean difference
	Mean	SD	Total	Mean	SD	Total	Weight	IV, random, 95%CI	IV, random, 95%CI
2.1.1 after 3 days
Liu et al. 2003 [10]	−0.4	1.32	24	0.4	1.91	26	53.9%	−0.48 (−1.04, 0.09)
Yang et al. 2004 [11]	−24.5	15.15	22	−3.6	15.95	15	46.1%	−1.32 (−2.05, −0.59)
Subtotal (95%Cl)			46			41	100.0%	−0.87 (−1.69, −0.04)
Heterogeneity: Tau^2 = 0.25; Chi-square = 3.23, df = 1 (𝑃 = 0.07); 𝐼^2 = 69%
Test for overall effect 𝑍 = 2.05 (𝑃 = 0.04)
2.1.2 after 7 days
Liu et al. 2003 [10]	−0.8	1.41	24	0.8	2.08	26	50.5%	−0.88 (−1.46, −0.30)
Zhang et al. 2008 [15]	−46.7	15.05	30	−16.3	15.36	30	49.5%	−1.97 (−2.60, −1.35)
Subtotal (95%Cl)			54			56	100.0%	−1.42 (−2.49, −0.35)
Heterogeneity: Tau^2 = 0.50; Chi-square = 6.30, df = 1 (𝑃 = 0.01); 𝐼^2 = 84%
Test for overall effect: 𝑍 = 2.60 (𝑃 = 0.009)
Test for subgroup differences: Chi-square = 0.65, df = 1 (𝑃 = 0.42), 𝐼^2 = 0%