Review Article

Sexually Transmitted Infections and Male Circumcision: A Systematic Review and Meta-Analysis

Table 13

Studies of the association between circumcision status and the prevalence of genital human papillomavirus infection.

StudyIntact +ve/−veCircumcised +ve/−veOdds ratio
95% confidence intervalExact odds ratioExact confidence interval

Aynaud et al. [33] 383/354119/1441.310.99–1.741.30890.9773–1.7551
Aynaud et al. [34] 93/6920/281.890.98–3.621.88120.9354–3.8412
Baldwin46/11246/1861.661.04–2.661.65851.0074–2.7333
Bleeker; group AA: 18/523/101.150.29–4.67 1.15190.2562–7.2315
Bleeker; group B93/678/20.350.07–1.690.34890.0350–1.8257
Castellsagué; Brazil 40/631/53.170.36–28.183.14700.3344–153.8345
Castellsagué; Columbia 52/1830/42.570.14–48.601.48490.1824–[12.0884]*
Castellsagué; Philippines 2/2012/2211.840.38–8.811.83620.1870–9.1816
Castellsagué; Spain 37/2781/364.790.64–35.994.77850.7551–199.6211
Castellsagué; Thailand 35/ 1362/354.501.03–19.644.48101.0600–40.2844
Giuliano et al. [102]; any HPVNANA0.970.68–1.390.970.68–1.39
Giuliano et al. [102]; high risk NANA0.930.63–1.330.930.63–1.33
Hernandez14/4452/1440.880.44–1.740.88160.4113–1.8042
Lajous 365/46528/671.88 1.18–2.981.87701.1631–3.0978
Mandal22/666/110.610.20–1.850.61420.1815–2.2693
Müller; any HPV125/2935/192.341.17–4.662.30921.0971–4.8997
Müller; high risk#80/7423/311.460.78–2.721.45450.7454–2.8691
Müller; low risk124/3034/202.431.23–4.812.41981.1521–5.0476
Ng’ayo136/968/101.770.67–4.651.76670.6028–5.3567
Nielson; any HPV38/36199/1901.010.61–1.661.00780.5942–1.7117
Nielson; high risk#23/51112/2270.91 0.53–1.570.91420.5062–1.6133
Oglivie; any HPV89/4194/380.880.52–1.490.87800.4997–1.5397
Oglivie; high risk#25/10538/940.590.33–1.050.59020.3160–1.0877
Oriel 151/6940/281.530.87–2.681.52950.8362–2.7769
Rombaldi47/427/30.480.12–1.970.48300.0758–2.2850
Shin 3/4029/2960.770.22–2.630.76600.1429–2.6506
Svare 84/894/204.781.57–14.554.68691.4852–19.6399
Vaccarella62/4706/2415.302.26–12.425.29052.2526–15.1850
Vardas; any HPV417/1598 247/9050.960.80–1.140.95610.7981–1.1469
Vardas; high risk161/1854115/10370.780.61–1.010.78310.6050–1.0161
Weaver STD clinic0/310/170.240.01–5.080.4826[0.0478]* –4.8700
Weaver University students17/4282/1760.870.47–1.620.86910.4365–1.6708
Random effects summary effects:Any HPV1.24111.02–1.51
High-risk HPV1.1661
0.94–1.45
8
Selective HPV1.01280.80–1.2

Brackets indicate that an infinite upper confidence interval was replaced with value equidistant from the odds ratio estimate as the lower confidence interval.
Data used in calculating Any HPV summary effect.
Data used in calculating high risk HPV summary effect.
Any HPV: Heterogeneity chi-square ( ) 39.98 ( ).
High-risk HPV: Heterogeneity chi-square ( ) 45.27 ( ).
Selective HPV: Heterogeneity chi-square ( ) 28.82 ( ).