International Scholarly Research Notices

Clinical Study

Improved Insulin Sensitivity during Pioglitazone Treatment Is Associated with Changes in IGF-I and Cortisol Secretion in Type 2 Diabetes and Impaired Glucose Tolerance

Table 3

Interstitial measurements in adipose tissue during OGTT in 10 subjects with type 2 diabetes (T2D) and 10 subjects with impaired glucose tolerance (IGT) at baseline (week 0) and after 12 weeks of pioglitazone treatment (mean ± SEM).


	T2D						IGT						T2D versus IGT
	Baseline week 0	Baseline week 12	ANOVA*	D-AUC week 0	D-AUC week 12		Baseline week 0	Baseline week 12	ANOVA*	D-AUC week 0	D-AUC week 12		baseline week 0	baseline week 12	D-AUC week 0	D-AUC week 12

Glucose (mmol/L)			0.269			0.600			0.210			0.161	0.005	0.169	0.008	0.011
Pyruvate (mol/L)			0.073			0.785			0.384			0.100	0.010	0.965	0.962	0.175
Lactate (mmol/L)			0.454			0.773			0.157			0.043	0.791	0.842	0.236	0.333
Glycerol (mol/L)			0.038			0.167			0.846				0.910	0.198	0.903	0.860

*Repeated measures ANOVA over the baseline period, for example, from −30 to + 30 minutes.