High Density Lipoprotein: Assembly, Structure, Cargo, and Functions
Figure 3
HDL signaling to eNOS through SR-B1 and S1P3. ApoA-I provokes a signalling cascade through SR-BI (green arrows) stimulating PI3K via Src. The lysophospholipids bind the S1P3 receptor and through the G proteins also stimulate PI3K (blue arrows). Cross-talk between the two pathways is depicted in red arrows implementing the involvement of Akt and MAPK amplifying the phosphorylation of eNOS.
