Biochemical Studies on Methylglyoxal-Mediated Glycated Histones: Implications for Presence of Serum Antibodies against the Glycated Histones in Patients with Type 1 Diabetes Mellitus

<table>Fluorescence emission spectra of native histone (—) and histone modified with 1 mM (<svg height="5.4250002" id="M8" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 19.450001 5.4250002" width="19.450001" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
<g transform="matrix(.017,-0,0,-.017,.062,5.363)"><path d="M215 255q0 -26 -16 -42t-40 -16q-25 0 -40.5 16t-15.5 42q0 24 16 40.5t40 16.5t40 -16.5t16 -40.5zM541 255q0 -26 -16 -42t-40 -16q-25 0 -40.5 16t-15.5 42q0 24 16 40.5t40 16.5t40 -16.5t16 -40.5zM867 255q0 -26 -16 -42t-40 -16q-25 0 -40.5 16t-15.5 42
q0 24 16 40.5t40 16.5t40 -16.5t16 -40.5z" id="x22EF"></path></g>
</svg>) and 2 mM (- -) methylglyoxal. Excitation, 320 nm.</table>

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Figure 4

Figure 4: Biochemical Studies on Methylglyoxal-Mediated Glycated Histones: Implications for Presence of Serum Antibodies against the Glycated Histones in Patients with Type 1 Diabetes Mellitus 

Figure 4 | Biochemical Studies on Methylglyoxal-Mediated Glycated Histones: Implications for Presence of Serum Antibodies against the Glycated Histones in Patients with Type 1 Diabetes Mellitus 