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| Molecular structure/antigen | Detection agent/technique | Properties and functional relevance |
|
| Identification* |
| Surface carbohydrates (oligosaccharides containing-galactose residues) | Griffonia (Bandeiraea) simplicifolia isolectin B4 | Not known, also expressed by blood vessels |
| Surface carbohydrates (oligosaccharides containing N-acetylglucosamine oligomers) | Lycopersicon esculentum (tomato) lectin | Not known, also expressed by blood vessels |
| Iba1 (ionized calcium-binding adaptormolecule 1) | Antibodies against Iba1 | Protein with suggested role in calcium homeostasis |
| CD11b/18 (αMβ2 integrin) | Antibodies against CD11b/CD18 (MAC1, OX42) | Complement receptor 3 (CR3) with additional binding properties for other molecules, for example, Fibrinogen |
| CD45 (leukocyte common antigen, LCA) | Antibodies against CD45, low expression compared with infiltrating leukocytes | Transmembrane protein tyrosine phosphatase, functions in signaling, also roles for TCR and BCR activity |
| CD68 (macrosialin) | Antibodies against CD68 | Role in Phagocytosis and as oxidized LDL-binding protein |
| F4/80 antigen | F4/80 antibody | Member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family, suggested role in immune tolerance |
|
| Functional orientation |
| MHC II | Antibodies against MHC II components, combinable with functional assays for antigen presentation to T cells in vitro | Antigen presentation by APC |
| CD11c (integrin αX) | Antibodies against CD11c | Cell adhesion, marker for dendritic cells as APC |
| CD34 (mucosialin, sialomucin) | Antibodies against CD34 | Roles in adhesion, marker for precursor cells of the myeloid lineage |
| iNOS (inducible nitric oxidesynthase) | Antibodies against iNOS, in situ hybridization indirectly by measurement of NO production via nitrite in vitro | Enzymatic synthesis of NO from arginine during inflammation (upon gene induction), resulting also in citrulline generation |
|
| Transgenic models |
| CX3CR1 | Transgenic Mice expressing enhanced green fluorescent protein (EGFP) in the Cx3cr1 locus (fractalkine receptor) | Receptor for the chemokine fractalkine (CX3CL1) with implications for the control of Microglial activity |
| Iba1 | Transgenic mice expressing enhanced green fluorescent protein (EGFP) under control of the Iba1promoter | Protein with suggested role in calcium homeostasis |
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