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ISRN Biochemistry
Volume 2013 (2013), Article ID 238428, 18 pages
http://dx.doi.org/10.1155/2013/238428
Review Article

Nanoparticles for Brain Drug Delivery

Department of Health Sciences, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy

Received 20 March 2013; Accepted 11 April 2013

Academic Editors: H. Itoh, H. Pant, and M. Seno

Copyright © 2013 Massimo Masserini. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [42 citations]

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  • Sama Sleiman, and Giovanni Coppola, “Epigenetics of Alzheimer's Disease and Frontotemporal Dementia,” Neurotherapeutics, vol. 10, no. 4, pp. 709–721, 2013. View at Publisher · View at Google Scholar
  • Catalina Anisoara Peptu, Lacramioara Ochiuz, Liana Alupei, Cristian Peptu, and Marcel Popa, “Carbohydrate Based Nanoparticles for Drug Delivery Across Biological Barriers,” Journal of Biomedical Nanotechnology, vol. 10, no. 9, pp. 2107–2148, 2014. View at Publisher · View at Google Scholar
  • Tanima Bose, Diane Latawiec, Partha Pratim Mondal, and Subhra Mandal, “Overview of nano-drugs characteristics for clinical application: the journey from the entry to the exit point,” Journal of Nanoparticle Research, vol. 16, no. 8, 2014. View at Publisher · View at Google Scholar
  • Stanley Bazarek, and Daniel A. Peterson, “Prospects for engineering neurons from local neocortical cell populations as cell-mediated therapy for neurological disorders,” Journal of Comparative Neurology, 2014. View at Publisher · View at Google Scholar
  • Aikaterini Lalatsa, and Andreas G. Schatzlein, “Strategies To Deliver Peptide Drugs to the Brain,” Molecular Pharmaceutics, vol. 11, no. 4, pp. 1081–1093, 2014. View at Publisher · View at Google Scholar
  • Dan Liu, Bingqian Lin, Wei Shao, Zhi Zhu, Tianhai Ji, and Chaoyong Yang, “In Vitro and in Vivo Studies on the Transport of PEGylated Silica Nanoparticles across the Blood-Brain Barrier,” Acs Applied Materials & Interfaces, vol. 6, no. 3, pp. 2131–2136, 2014. View at Publisher · View at Google Scholar
  • Kavitha Siva, Giuseppina Covello, and Michela A. Denti, “Exon-Skipping Antisense Oligonucleotides to Correct Missplicing in Neurogenetic Diseases,” Nucleic Acid Therapeutics, vol. 24, no. 1, pp. 69–86, 2014. View at Publisher · View at Google Scholar
  • David J. Mc Carthy, Meenakshi Malhotra, Aoife M. O’Mahony, John F. Cryan, and Caitriona M. O’Driscoll, “Nanoparticles and the Blood-Brain Barrier: Advancing from In-Vitro Models Towards Therapeutic Significance,” Pharmaceutical Research, 2014. View at Publisher · View at Google Scholar
  • Genaro Gabriel Ortiz, Fermín Paul Pacheco-Moisés, Miguel Ángel Macías-Islas, Luis Javier Flores-Alvarado, Mario A. Mireles-Ramírez, Erika Daniela González-Renovato, Vanessa Elizabeth Hernández-Navarro, Angélica Lizeth Sánchez-López, and Moisés Alejandro Alatorre-Jiménez, “Role of the Blood-Brain Barrier in Multiple Sclerosis,” Archives of Medical Research, 2014. View at Publisher · View at Google Scholar
  • Hasan Ebrahimi Shahmabadi, Fatemeh Movahedi, Maedeh Koohi Moftakhari Esfahani, Seyed Ebrahim Alavi, Ali Eslamifar, Gholamreza Mohammadi Anaraki, and Azim Akbarzadeh, “Efficacy of Cisplatin-loaded polybutyl cyanoacrylate nanoparticles on the glioblastoma,” Tumor Biology, 2014. View at Publisher · View at Google Scholar
  • Lucas Cordeiro, Larissa Müller, Marcos A. Gelesky, Wilson Wasielesky, Daniele Fattorini, Francesco Regoli, José Marìa Monserrat, and Juliane Ventura-Lima, “Evaluation of coexposure to inorganic arsenic and titanium dioxide nanoparticles in the marine shrimp Litopenaeus vannamei,” Environmental Science and Pollution Research, 2015. View at Publisher · View at Google Scholar
  • Marlies Gijs, An Aerts, Nathalie Impens, Sarah Baatout, and André Luxen, “Aptamers as radiopharmaceuticals for nuclear imaging and therapy,” Nuclear Medicine and Biology, 2015. View at Publisher · View at Google Scholar
  • Clarence S. Yah, and Geoffrey S. Simate, “Nanoparticles as potential new generation broad spectrum antimicrobial agents,” DARU Journal of Pharmaceutical Sciences, vol. 23, no. 1, 2015. View at Publisher · View at Google Scholar
  • Maysam Pedram, Amir Shamloo, Aria Alasty, and Ebrahim Ghafar-Zadeh, “Toward Epileptic Brain Region Detection Based on Magnetic Nanoparticle Patterning,” Sensors, vol. 15, no. 9, pp. 24409–24427, 2015. View at Publisher · View at Google Scholar
  • Lingzhou Zhao, Jingyi Zhu, Yongjun Cheng, Zhijuan Xiong, Yueqin Tang, Lilei Guo, Xiangyang Shi, and Jinhua Zhao, “ Chlorotoxin-Conjugated Multifunctional Dendrimers Labeled with Radionuclide 131 I for Single Photon Emission Computed Tomography Imaging and Radiotherapy of Gliomas ,” ACS Applied Materials & Interfaces, pp. 150825105741001, 2015. View at Publisher · View at Google Scholar
  • Yasaman Hosseini, Seyed Ebrahim Alavi, Azim Akbarzadeh, and Amir Heidarinasab, “Improving lithium carbonate therapeutics by pegylated liposomal technology: an in vivo study,” Comparative Clinical Pathology, 2015. View at Publisher · View at Google Scholar
  • Yukio Takeshita, and Richard M. Ransohoff, “Blood-brain barrier and neurological diseases,” Clinical and Experimental Neuroimmunology, 2015. View at Publisher · View at Google Scholar
  • Yuliana Monsalve, Giovanni Tosi, Barbara Ruozi, Daniela Belletti, Antonietta Vilella, Michele Zoli, Maria Angela Vandelli, Flavio Forni, Betty L López, and Ligia Sierra, “PEG-g-chitosan nanoparticles functionalized with the monoclonal antibody OX26 for brain drug targeting,” Nanomedicine, vol. 10, no. 11, pp. 1735–1750, 2015. View at Publisher · View at Google Scholar
  • Deepak Sharma, Rakesh Kumar Sharma, Navneet Sharma, Reema Gabrani, Sanjeev K. Sharma, Javed Ali, and Shweta Dang, “Nose-To-Brain Delivery of PLGA-Diazepam Nanoparticles,” AAPS PharmSciTech, 2015. View at Publisher · View at Google Scholar
  • Julie T.-W. Wang, Noelia Rubio, Houmam Kafa, Enrica Venturelli, Chiara Fabbro, Cécilia Ménard-Moyon, Tatiana Da Ros, Jane K. Sosabowski, Alastair D. Lawson, Martyn K. Robinson, Maurizio Prato, Alberto Bianco, Frederic Festy, Jane E. Preston, Kostas Kostarelos, and Khuloud T. Al-Jamal, “Kinetics of functionalised carbon nanotube distribution in mouse brain after systemic injection: Spatial to ultra-structural analyses,” Journal of Controlled Release, 2015. View at Publisher · View at Google Scholar
  • Monique Culturato Padilha Mendonça, Edilene Siqueira Soares, Marcelo Bispo de Jesus, Helder José Ceragioli, Mônica Siqueira Ferreira, Rodrigo Ramos Catharino, and Maria Alice da Cruz-Höfling, “Reduced graphene oxide induces transient blood–brain barrier opening: an in vivo study,” Journal of Nanobiotechnology, vol. 13, no. 1, 2015. View at Publisher · View at Google Scholar
  • Louiza Bohn Thomsen, Maj Schneider Thomsen, and Torben Moos, “Targeted drug delivery to the brain using magnetic nanoparticles,” Therapeutic Delivery, 2015. View at Publisher · View at Google Scholar
  • Christopher J. Cheng, Gregory T. Tietjen, Jennifer K. Saucier-Sawyer, and W. Mark Saltzman, “A holistic approach to targeting disease with polymeric nanoparticles,” Nature Reviews Drug Discovery, 2015. View at Publisher · View at Google Scholar
  • Washington Chigumira, Prosper Maposa, Louis L. Gadaga, Admire Dube, Dexter Tagwireyi, and Charles C. Maponga, “Preparation and Evaluation of Pralidoxime-Loaded PLGA Nanoparticles as Potential Carriers of the Drug across the Blood Brain Barrier,” Journal of Nanomaterials, vol. 2015, pp. 1–5, 2015. View at Publisher · View at Google Scholar
  • Meenakshi Malhotra, André Toulouse, Bruno M. D. C. Godinho, David John Mc Carthy, John F. Cryan, and Caitriona M. O'Driscoll, “RNAi therapeutics for brain cancer: current advancements in RNAi delivery strategies,” Mol. BioSyst., vol. 11, no. 10, pp. 2635–2657, 2015. View at Publisher · View at Google Scholar
  • Beniamino Palmieri, Dimitri Poddighe, Maria Vadalà, Carmen Laurino, Carla Carnovale, and Emilio Clementi, “Severe somatoform and dysautonomic syndromes after HPV vaccination: case series and review of literature,” Immunologic Research, 2016. View at Publisher · View at Google Scholar
  • Vimala N. Bharadwaj, Jonathan Lifshitz, P. David Adelson, Vikram D. Kodibagkar, and Sarah E. Stabenfeldt, “Temporal assessment of nanoparticle accumulation after experimental brain injury: Effect of particle size,” Scientific Reports, vol. 6, pp. 29988, 2016. View at Publisher · View at Google Scholar
  • Maysam Z. Pedram, Amir Shamloo, Ebrahim GhafarZadeh, and Aria Alasty, “Dynamic analysis of magnetic nanoparticles crossing cell membrane,” Journal of Magnetism and Magnetic Materials, 2016. View at Publisher · View at Google Scholar
  • Ronak Savla, and Tamara Minko, “Nanoparticle design considerations for molecular imaging of apoptosis: Diagnostic, prognostic, and therapeutic value,” Advanced Drug Delivery Reviews, 2016. View at Publisher · View at Google Scholar
  • Maysam Pedram, Amir Shamloo, Aria Alasty, and Ebrahim Ghafar-Zadeh, “Optimal Magnetic Field for Crossing Super-Para-Magnetic Nanoparticles through the Brain Blood Barrier: A Computational Approach,” Biosensors, vol. 6, no. 2, pp. 25, 2016. View at Publisher · View at Google Scholar
  • Cláudia Saraiva, Catarina Praça, Raquel Ferreira, Tiago Santos, Lino Ferreira, and Liliana Bernardino, “Nanoparticle-mediated brain drug delivery: Overcoming blood-brain barrier to treat neurodegenerative diseases,” Journal of Controlled Release, 2016. View at Publisher · View at Google Scholar
  • Mihaela Aldea, Ioan Alexandru Florian, Gabriel Kacso, Lucian Craciun, Sanda Boca, Olga Soritau, and Ioan Stefan Florian, “Nanoparticles for Targeting Intratumoral Hypoxia: Exploiting a Potential Weakness of Glioblastoma,” Pharmaceutical Research, 2016. View at Publisher · View at Google Scholar
  • Yu Zhang, Jason S. Buhrman, Yang Liu, Jamie E. Rayahin, and Richard A. Gemeinhart, “Reducible Micelleplexes are Stable Systems for Anti-miRNA Delivery in Cerebrospinal Fluid,” Molecular Pharmaceutics, 2016. View at Publisher · View at Google Scholar
  • Ivana Cacciatore, Michele Ciulla, Erika Fornasari, Lisa Marinelli, and Antonio Di Stefano, “Solid lipid nanoparticles as a drug delivery system for the treatment of neurodegenerative diseases,” Expert Opinion on Drug Delivery, pp. 1–11, 2016. View at Publisher · View at Google Scholar
  • Maedeh Koohi Moftakhari Esfahani, Seyed Ebrahim Alavi, Shahedeh Shahbazian, and Hasan Ebrahimi Shahmabadi, “Drug Delivery of Cisplatin to Breast Cancer by Polybutylcyanoacrylate Nanoparticles,” Advances in Polymer Technology, 2016. View at Publisher · View at Google Scholar
  • Kayla Miller, Suraj Dixit, Amy-Lee Bredlau, Alfred Moore, Emilie McKinnon, and Ann-Marie Broome, “Delivery of a drug cache to glioma cells overexpressing platelet-derived growth factor receptor using lipid nanocarriers,” Nanomedicine, 2016. View at Publisher · View at Google Scholar
  • Inmaculada Posadas, Silvia Monteagudo, and Valentín Ceña, “Nanoparticles for brain-specific drug and genetic material delivery, imaging and diagnosis,” Nanomedicine, 2016. View at Publisher · View at Google Scholar
  • Shubhra Chaturvedi, and Anil K. Mishra, “Small Molecule Radiopharmaceuticals – A Review of Current Approaches,” Frontiers in Medicine, vol. 3, 2016. View at Publisher · View at Google Scholar
  • S. Aday, R. Cecchelli, D. Hallier-Vanuxeem, M.P. Dehouck, and L. Ferreira, “Stem Cell-Based Human Blood–Brain Barrier Models for Drug Discovery and Delivery,” Trends in Biotechnology, 2016. View at Publisher · View at Google Scholar
  • André M. Emilie, Passirani Catherine, Seijo Begona, Sanchez Alejandro, and Montero-Menei Claudia N, “Nano and microcarriers to improve stem cell behaviour for neuroregenerative medicine strategies: application to Huntington’s disease,” Biomaterials, 2016. View at Publisher · View at Google Scholar
  • Rohit S. Mulik, Chenchen Bing, Michelle Ladouceur-Wodzak, Imalka Munaweera, Rajiv Chopra, and Ian R. Corbin, “Localized Delivery of Low-Density Lipoprotein Docosahexaenoic Acid Nanoparticles to the Rat Brain using Focused Ultrasound,” Biomaterials, 2016. View at Publisher · View at Google Scholar
  • Tian-Tian Zhang, Wen Li, Guanmin Meng, Pei Wang, and Wenzhen Liao, “Strategies for transporting nanoparticles across the blood–brain barrier,” Biomater. Sci., vol. 4, no. 2, pp. 219–229, 2016. View at Publisher · View at Google Scholar