Review Article

Identification, Evaluation, and Treatment of Patients with Hereditary Cancer Risk within the United States

Table 1

USPSTF increased-risk family history patterns.

Non-Ashkenazi Jewish women
 Two first-degree relatives with breast cancer (at least 1
 under age 50 at diagnosis)
 Three or more first- or second-degree relatives with breast
 cancer at any age
 Both breast and ovarian cancer among first- or second-degree
 relatives
 A first-degree relative with bilateral breast cancer
 Two or more first- or second-degree relatives with ovarian
 cancer at any age
 A first- or second-degree relative with both breast and ovarian
 cancer
 Male relative with breast cancer
Women of Jewish ancestry
 Any first-degree relative (or 2 second-degree relatives on
 the same side of the family) with breast or ovarian cancer