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An affected individual with one or more of the following | An unaffected individual with a family history of one or more of the following |
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A known mutation in a breast cancer susceptibility gene within the family | A known mutation in a breast cancer susceptibility gene within the family |
Early age of onset (≤50 years) | ≥2 breast primaries in a single individual |
Triple negative (ER-, PR-, HER2-) breast cancer | ≥2 individuals with breast primaries on the same side of the family |
Two breast cancer primaries in a single individual |
Breast cancer at any age and 1 of the following: | ≥1 ovarian cancer primary from the same side of the family |
≥1 close blood relative with breast cancer <50 y |
≥1 close blood relative with epithelial ovarian cancer (any age) | First- or second-degree relative with breast cancer ≤45 y |
≥2 close blood relatives with breast cancer and/or pancreatic cancer at any age | |
From a population at increased risk | |
≥1 family member on same side of family with a combination of breast cancer and ≥1 of following: pancreatic cancer, aggressive prostate cancer, sarcoma, adrenocortical carcinoma, brain tumors, endometrial cancer, leukemia/lymphoma, thyroid cancer, dermatologic manifestations and/or macrocephaly, hamartomatous polyps of GI tract, and diffuse gastric cancer | ≥1 family member on same side of family with a combination of breast cancer and ≥1 of following: pancreatic cancer, aggressive prostate cancer, sarcoma, adrenocortical carcinoma, brain tumors, endometrial cancer, leukemia/lymphoma, thyroid cancer, dermatologic manifestations and/or macrocephaly, hamartomatous polyps of GI tract, and diffuse gastric cancer |
Ovarian cancer | Male breast cancer |
Male breast cancer | |
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