Amelogenin Peptide Extract Increases Differentiation and Angiogenic and Local Factor Production and Inhibits Apoptosis in Human Osteoblasts

Figure 7

Protective effect of rhAmelogenin and Fraction C on osteoblast apoptosis. MG63 cells were grown to confluence. Cultures were pretreated for 30 minutes with 10 μM chelerythrine to induce apoptosis and then treated with rhAmelogenin or Fraction C. MTT (a), DNA fragmentation (b), caspase-3 activity (c), and phospho-p53 (d) were measured. *𝑃<0.05, versus 0 μg/mL; ^•𝑃<0.05, versus 1 μg/mL.

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