Research Article
Comparing Drug-Drug Interaction Severity Ratings between Bedside Clinicians and Proprietary Databases
Table 2
Drug-drug interaction rating scale [
14,
15].
| Rating | Designation |
Explanation |
| X | Contraindicated | Avoid combination | The drugs are contraindicated for concurrent use | D | Major | Consider therapy modification | The interaction may be life threatening and/or require medical | intervention to minimize or prevent serious adverse events | C | Moderate | Monitor therapy | The interaction may result in exacerbation of the patient's | condition and/or require an alteration in therapy | B | Minor | No action needed | The interaction would have limited clinical effects. May include an | increase in the frequency or severity of the side effects, but | generally it would not require a major alteration in therapy | A | Unknown | No known interaction | Unknown |
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