365916.fig.001a
(a)
365916.fig.001b
(b)
Figure 1: B-cell subpopulations of index patient and healthy sibling. (a) B cell subpopulations of index patient, showing 94.1% naïve + transitional B cells (IgM+IgD+CD27−), 1.1% Marginal Zone B cells (IgM+IgD+CD27+), 0.1% class-switched B cells (IgD−IgM−CD27+) and 13.3% transitional B cells (IgD+CD38+). (b) B cell subpopulations of healthy sibling, showing 75.6% naïve + transitional B cells (IgM+IgD+CD27−), 9.4% Marginal Zone B cells (IgM+IgD+CD27+), 9% class-switched B cells (IgD−IgM−CD27+), and 6.5% transitional B cells (IgD+CD38+).