Table 1: Immunological characteristics of patient and family.

PatientSibling 1Sibling 2MotherFather

Gender
Age (yrs)1116144343
TACI variantC104R + A181EC104R + A181EC104R + A181EA181EC104R
InfectionsYesInitially no, later yesNoNoNo
IgG2.3 4.87 8.3714.211.4
IgA0.12 0.36 0.45 1.71.1
IgM0.20 0.59 0.921.40.78
IgG11.5 3.3 5.79.8 ↑7.6
IgG20.11 0.5 1.273.362.08
IgG31.66 ↑0.520.541.000.87
IgG4<0.070.04 0.180.050.24

Specific Ab titer after vaccination pneumococcal serotype (IU/mL) ( g/mL)( g/mL)( g/mL)( g/mL)

11.47.215>40
31 1.26.17.02.6
42 0.46 6.20.89 1
54.00.34 2.46.9
6B0.050 1.5110.65
7F1.7191.215
9V2 0.97 6.66.94.5
143.1>401139
18C0.49 0.70 3.75.2
19F0.48 >403912
23F1.81.42311

Anti-Hib IgG31>100>1008.71.6

Numbers with ↑ indicate values ≥2 standard deviations (SD) above the references values; are numbers ≤2 SD age-related references values. ♀: female; ♂: male; Ab: antibody; Ig: immunoglobulin; TACI: transmembrane activator, calcium modulator, and cyclophilin ligand interactor; Hib: Haemophilus influenzae type B.