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ISRN Neurology
Volume 2013 (2013), Article ID 375852, 5 pages
http://dx.doi.org/10.1155/2013/375852
Review Article

Noncoding RNAs in Neurodegenerative Diseases

1Department of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL 36849, USA
2Department of Physical Sciences, Auburn University at Montgomery, Montgomery, AL 36117, USA
3Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn, AL 36849, USA

Received 27 February 2013; Accepted 10 April 2013

Academic Editors: A. Conti and T. Müller

Copyright © 2013 Shraddha D. Rege et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Noncoding RNAs are widely known for their various essential roles in the development of central nervous system. It involves neurogenesis, neural stem cells generation, maintenance and maturation, neurotransmission, neural network plasticity, formation of synapses, and even brain aging and DNA damage responses. In this review, we will discuss the biogenesis of microRNA, various functions of noncoding RNA's specifically microRNAs (miRNAs) that act as the chief regulators of gene expression, and focus in particular on misregulation of miRNAs which leads to several neurodegenerative diseases as well as its therapeutic outcome. Recent evidences has shown that miRNAs expression levels are changed in patients with neurodegenerative diseases; hence, miRNA can be used as a potential diagnostic biomarker and serve as an effective therapeutic tool in overcoming various neurodegenerative disease processes.