Review Article
Pentraxins: Structure, Function, and Role in Inflammation
Table 2
Overview of pentraxin receptors.
| | Receptor | Cells | | Other ligands | Functions |
| | FcγRI (CD64) | Monocytes, macrophages, DC, inducible on PMN | Activating | High affinity for IgG | Antibody-dependent cell-mediated cytotoxicity
Phagocytosis |
| | FcγRIIA/C (CD32A/C) | Monocytes, macrophages, DC neutrophils, platelets | Activating | IgG | Antibody-dependent cell-mediated cytotoxicity
Phagocytosis
Platelet activation |
| | FcγRIIB (CD32B) | B lymphocytes, macrophages, DC | Inhibitory | IgG | Regulation of responses through immunoreceptors |
| | FcγRIIIA (CD16A) | Macrophages, some monocytes, NK cells | Activating | IgG | Antibody-dependent cell-mediated cytotoxicity
Phagocytosis |
| | FcγRIIIB (CD16B) | PMNs | GPI-linked | IgG | Immune complex binding
Activation of FcRIIA |
| | FcαRI (CD89) | Monocytes, macrophages, DC neutrophils, platelets | Activating/inhibitory | IgA | Phagocytosis
Regulation of responses through other receptors |
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