Synergistic Radioprotection by Gamma-Tocotrienol and Pentoxifylline: Role of cAMP Signaling
Figure 1
GT3-PTX combination increased the radioprotective efficacy of GT3 at 11.5 Gy. Postirradiation survival studies were conducted on mice () treated with GT3 or PTX or a combination of GT3 and PTX. (a) shows time optimization studies on GT3 (200 mg/kg) and PTX (100 mg/kg) combination. GT3-PTX (−15 min) combination provided significantly greater protection than GT3 (). All groups treated with GT3 alone or in combination with PTX significantly improved the survival in mice compared to vehicle (). (b) shows that 100 mg/kg and 200 mg/kg of PTX significantly increased survival over GT3 alone (). There was PTX-dose dependent increase in radioprotection but statistically it was not significant.
