390379.fig.001a
(a)
390379.fig.001b
(b)
Figure 1: GT3-PTX combination increased the radioprotective efficacy of GT3 at 11.5 Gy. Postirradiation survival studies were conducted on mice ( ) treated with GT3 or PTX or a combination of GT3 and PTX. (a) shows time optimization studies on GT3 (200 mg/kg) and PTX (100 mg/kg) combination. GT3-PTX (−15 min) combination provided significantly greater protection than GT3 ( ). All groups treated with GT3 alone or in combination with PTX significantly improved the survival in mice compared to vehicle ( ). (b) shows that 100 mg/kg and 200 mg/kg of PTX significantly increased survival over GT3 alone ( ). There was PTX-dose dependent increase in radioprotection but statistically it was not significant.