390379.fig.008a
(a)
390379.fig.008b
(b)
390379.fig.008c
(c)
Figure 8: Effect of mevalonate and calmodulin on radioprotection by the GT3-PTX combination. Postirradiation survival study was conducted in mice ( ) treated with GT3, GT3-PTX, GT3-PTX-mevalonate, or GT3-PTX-calmodulin. (a) shows % survival over 30 days in mice treated with 200 mg/kg of GT3 (−24 h), 200 mg/kg of PTX (−15 min) with and without 30mg/kg of mevalonate (−24h). (b) shows % survival over 30 days in mice treated with 200mg/kg of GT3 (−24 h), 200mg/kg of PTX (−15 min) with and without 2000μ/kg of calmodulin (−15min). Calmodulin reduced the % survival ( ) when given in combination with GT3 and PTX. (c) shows the histogram of % survival in various treatment groups at the end of 30 days.