Table 3: Target organ damage in chronic sinoaortic denervated rats.

TissueAlterations

Heart Late left ventricular hypertrophy
Impairment of diastolic function in both left and right ventricle
Increase cardiac expression of type I and III collagen
Interstitial fibrosis and wall thickening

VesselsAortic hypertrophy
Increase in wall thickness
Collagen accumulation
Smooth muscle cell growth
Impaired arterial distensibility

KidneyIncrease in mesangial matrix
Glomerular collapse
Fibrohyalinosis
Thickening of basement membrane of Bowman’s capsule