Multiple Congenital Anomalies after Assisted Reproductive Technology in Japan (between 2004 and 2009)
Table 2
Demographic and perinatal outcome between isolated and multiple congenital anomalies.
Isolated
MCAs
()
()
%
%
Method of fertility treatment
IVF
239
24.4
25
26.0
ICSI
236
24.1
22
22.9
IVF and ICSI
40
4.1
5
5.2
Frozen embryo transfer
463
47.2
44
45.8
0.930a
Unknown/missing values
2
0.2
0
0.0
Blastocyst transfer
Yes
507
51.7
48
50.0
No
464
47.3
48
50.0
0.679a
Unknown/missing values
9
0.9
0
0.0
Maternal age
Range
23–45
24–42
Mean ± SD
34.3 ± 3.9
34.0 ± 3.8
0.459b
Median
34
34
Gestational weeks
Range
20–42
21–41
Mean ± SD
37.2 ± 3.7
36.7 ± 3.9
0.234b
Median
38
37
Unknown/missing values
19
2
Plurality
Singletons
791
80.7
73
76.0
Multiple births
188
19.2
21
21.9
0.463a
Unknown/missing values
1
0.1
2
2.1
Sex (fetuses/neonates)
Male
547
55.8
52
54.2
Female
409
41.7
37
38.5
0.825a
Unknown/missing values
24
2.4
7
7.3
Perinatal outcome (fetuses/neonates)
Stillbirths (20 weeks)
25
2.6
4
4.2
Live births
955
97.4
92
95.8
0.351a
Unknown/missing values
0
0.0
0
0.0
Early neonatal death (neonatal death up to day 6 after birth)
Yes
35
3.7
9
9.8
No
687
71.9
63
68.5
0.007a
Unknown/missing values
233
24.4
20
21.7
MCAs: multiple congenital anomalies, IVF: in vitro fertilization, ICSI: intracytoplasmic sperm injection. n.s.: not significant.
a test, b-test. Unknown/missing values were excluded from the statistical tests.
