| Clinical syndrome | References |
| Paradoxical cryptococcal IRIS |
| Meningitis | [13, 130, 135, 136, 138–140, 145, 149, 150, 154–158] | Other CNS-IRIS manifestations | | (i) Intracranial space-occupying lesion/s | [136, 146, 159, 160] | (ii) Meningoradiculitis | [163] | (iii) Hearing loss | [161] | Lymphadenopathy | [135, 136, 145, 147, 151, 158, 164] | Cutaneous and/or soft-tissue lesions | [130, 165, 176] | Pneumonia or pulmonary nodules | [130, 136, 145] |
| ART-associated cryptococcal IRIS |
| Unmasking meningitis | [129, 135] | Lymphadenopathy | [166, 169] | Cutaneous and/or soft-tissue lesions | [168, 170] | Pneumonia | [167] |
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