Research Article
Microsatellite Instability in Head and Neck Squamous Cell Carcinoma: A Study of a Brazilian Population
Table 4
Marker genotypic frequencies, according to clinical and epidemiological features.
| Features | Genotypic frequencies | D3S1611 | P | D5S346 | P | D10S197 | P | HT | f | HM | f | HT | f | HM | f | HT | f | HM | f |
| Total | 26 | 0.703 | 11 | 0.297 | — | 23 | 0.821 | 5 | 0.179 | — | 29 | 0.879 | 4 | 0.121 | — | Gender | | | | | | | | | | | | | | | | Female | 6 | 0.750 | 2 | 0.250 | — | 7 | 0.875 | 1 | 0.125 | — | 8 | 1.0 | 0 | 0.0 | — | Male | 20 | 0.690 | 9 | 0.310 | | 16 | 0.800 | 4 | 0.200 | | 21 | 0.840 | 4 | 0.160 | | Age range, yrs | | | | | | | | | | | | | | | | ≤50 | 7 | 0.875 | 1 | 0.125 | 0.448 | 5 | 1.0 | 0 | 0.0 | 0.513 | 6 | 1.0 | 0 | 0.0 | 0.586 | 50–70 | 14 | 0.636 | 8 | 0.364 | | 14 | 0.778 | 4 | 0.222 | | 16 | 0.842 | 3 | 0.158 | | >70 | 5 | 0.714 | 2 | 0.286 | | 4 | 0.800 | 1 | 0.200 | | 7 | 0.875 | 1 | 0.125 | | Tumor site | | | | | | | | | | | | | | | | Oral cavity | 9 | 0.600 | 6 | 0.400 | — | 11 | 0.786 | 3 | 0.214 | — | 12 | 0.857 | 2 | 0.143 | — | Oropharynx | 6 | 0.750 | 2 | 0.250 | | 6 | 1.0 | 0 | 0.0 | | 7 | 0.875 | 1 | 0.125 | | Larynx | 11 | 0.786 | 3 | 0.214 | | 6 | 0.750 | 2 | 0.250 | | 10 | 0.909 | 1 | 0.091 | | Differentiation | | | | | | | | | | | | | | | | Well | 8 | 1.0 | 0 | 0.0 | 0.115 | 7 | 1.0 | 0 | 0.0 | 0.334 | 7 | 1.0 | 0 | 0.0 | 0.518 | Moderately | 13 | 0.619 | 8 | 0.381 | | 11 | 0.786 | 3 | 0.214 | | 15 | 0.833 | 3 | 0.167 | | Poorly | 5 | 0.625 | 3 | 0.375 | | 5 | 0.714 | 2 | 0.286 | | 7 | 0.875 | 1 | 0.125 | |
| Features |
Genotypic frequencies | D11S922 | P | D11S988 | P | D17S250 | P | HT | f | HM | f | HT | f | HM | f | HT | f | HM | f |
| Total | 19 | 0.760 | 6 | 0.240 | — | 26 | 0.867 | 4 | 0.133 | — | 28 | 0.875 | 4 | 0.125 | — | Gender | | | | | | | | | | | | | | | | Female | 7 | 0.875 | 1 | 0.125 | — | 8 | 1.0 | 0 | 0.0 | — | 7 | 0.875 | 1 | 0.125 | — | Male | 12 | 0.706 | 5 | 0.294 | | 18 | 0.818 | 4 | 0.182 | | 21 | 0.875 | 3 | 0.125 | | Age range, yrs | | | | | | | | | | | | | | | | ≤50 | 4 | 0.800 | 1 | 0.200 | 0.413 | 5 | 1.0 | 0 | 0.0 | 0.171 | 5 | 0.833 | 1 | 0.167 | 0.912 | 50–70 | 11 | 0.688 | 5 | 0.313 | | 13 | 0.765 | 4 | 0.235 | | 17 | 0.895 | 2 | 0.105 | | >70 | 4 | 1.0 | 0 | 0.0 | | 8 | 1.0 | 0 | 0.0 | | 6 | 0.857 | 1 | 0.143 | | Tumor site | | | | | | | | | | | | | | | | Oral cavity | 9 | 0.692 | 4 | 0.308 | — | 11 | 0.917 | 1 | 0.083 | — | 12 | 0.923 | 1 | 0.077 | — | Oropharynx | 6 | 1.0 | 0 | 0.0 | | 7 | 0.875 | 1 | 0.125 | | 8 | 1.0 | 0 | 0.0 | | Larynx | 4 | 0.667 | 2 | 0.333 | | 8 | 0.800 | 2 | 0.200 | | 8 | 0.727 | 3 | 0.273 | | Differentiation | | | | | | | | | | | | | | | | Well | 6 | 0.857 | 1 | 0.143 | 0.586 | 7 | 1.0 | 0 | 0.0 | 0.436 | 6 | 0.857 | 1 | 0.143 | 0.986 | Moderately | 10 | 0.769 | 3 | 0.231 | | 12 | 0.800 | 3 | 0.200 | | 15 | 0.882 | 2 | 0.118 | | Poorly | 3 | 0.600 | 2 | 0.400 | | 7 | 0.875 | 1 | 0.125 | | 7 | 0.875 | 1 | 0.125 | |
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HT: heterozygote; HM: homozygote; f: frequency; P: significance value.
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