Microsatellite Instability in Head and Neck Squamous Cell Carcinoma: A Study of a Brazilian Population

Table 4

Marker genotypic frequencies, according to clinical and epidemiological features.

Features	Genotypic frequencies
	D3S1611				P	D5S346				P	D10S197				P
	HT	f	HM	f		HT	f	HM	f		HT	f	HM	f
Total	26	0.703	11	0.297	—	23	0.821	5	0.179	—	29	0.879	4	0.121	—
Gender
Female	6	0.750	2	0.250	—	7	0.875	1	0.125	—	8	1.0	0	0.0	—
Male	20	0.690	9	0.310		16	0.800	4	0.200		21	0.840	4	0.160
Age range, yrs
≤50	7	0.875	1	0.125	0.448	5	1.0	0	0.0	0.513	6	1.0	0	0.0	0.586
50–70	14	0.636	8	0.364		14	0.778	4	0.222		16	0.842	3	0.158
>70	5	0.714	2	0.286		4	0.800	1	0.200		7	0.875	1	0.125
Tumor site
Oral cavity	9	0.600	6	0.400	—	11	0.786	3	0.214	—	12	0.857	2	0.143	—
Oropharynx	6	0.750	2	0.250		6	1.0	0	0.0		7	0.875	1	0.125
Larynx	11	0.786	3	0.214		6	0.750	2	0.250		10	0.909	1	0.091
Differentiation
Well	8	1.0	0	0.0	0.115	7	1.0	0	0.0	0.334	7	1.0	0	0.0	0.518
Moderately	13	0.619	8	0.381		11	0.786	3	0.214		15	0.833	3	0.167
Poorly	5	0.625	3	0.375		5	0.714	2	0.286		7	0.875	1	0.125
Features	Genotypic frequencies
	D11S922				P	D11S988				P	D17S250				P
	HT	f	HM	f		HT	f	HM	f		HT	f	HM	f
Total	19	0.760	6	0.240	—	26	0.867	4	0.133	—	28	0.875	4	0.125	—
Gender
Female	7	0.875	1	0.125	—	8	1.0	0	0.0	—	7	0.875	1	0.125	—
Male	12	0.706	5	0.294		18	0.818	4	0.182		21	0.875	3	0.125
Age range, yrs
≤50	4	0.800	1	0.200	0.413	5	1.0	0	0.0	0.171	5	0.833	1	0.167	0.912
50–70	11	0.688	5	0.313		13	0.765	4	0.235		17	0.895	2	0.105
>70	4	1.0	0	0.0		8	1.0	0	0.0		6	0.857	1	0.143
Tumor site
Oral cavity	9	0.692	4	0.308	—	11	0.917	1	0.083	—	12	0.923	1	0.077	—
Oropharynx	6	1.0	0	0.0		7	0.875	1	0.125		8	1.0	0	0.0
Larynx	4	0.667	2	0.333		8	0.800	2	0.200		8	0.727	3	0.273
Differentiation
Well	6	0.857	1	0.143	0.586	7	1.0	0	0.0	0.436	6	0.857	1	0.143	0.986
Moderately	10	0.769	3	0.231		12	0.800	3	0.200		15	0.882	2	0.118
Poorly	3	0.600	2	0.400		7	0.875	1	0.125		7	0.875	1	0.125

HT: heterozygote; HM: homozygote; f: frequency; P: significance value.