Nonneuronal Cholinergic System in Breast Tumors and Dendritic Cells: Does It Improve or Worsen the Response to Tumor?

<table>Cholinergic actions on human dendritic cells (DCs). DCs express all the components of the nonneuronal cholinergic system: muscarinic acetylcholine receptors (mAChR), acetylcholine transferase (AChT), and acetylcholinesterase (AChE). The activation of mAChR with carbachol (Carb) in immature DCs (iDCs) upregulates deexpression of HLA-DR and the liberation of tumor necrosis factor (TNF) and interleukin-8 (IL-8) and stimulates demix lymphocyte reaction (MLR), while the activation of mAChR with Carb in mature DCs (mDCs) downregulates HLA-DR, TNF, and IL-12 and reduces MLR.</table>

International Scholarly Research Notices

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Figure 3: Nonneuronal Cholinergic System in Breast Tumors and Dendritic Cells: Does It Improve or Worsen the Response to Tumor? 