Development and Validation of a Stability Indicating RP-HPLC Method for the Determination of Two Sun Protection Factors (Koptrizon and Tinosorb S) in Topical Pharmaceutical Formulations Using Experimental Designs

Figure 4

Single factor interaction: (a) flow rate in RT of KPT; (b) column temperature in KPT; (c) THF composition in KPT; (d) flow rate in RT of TIN; (e) column temperature in RT of TIN; (f) THF composition in RT of TIN; (g) flow rate in USP plate count of KPT; (h) column temperature in USP plate count of KPT; (i) THF composition in USP plate count KPT.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)