Development and Validation of a Stability Indicating RP-HPLC Method for the Determination of Two Sun Protection Factors (Koptrizon and Tinosorb S) in Topical Pharmaceutical Formulations Using Experimental Designs
Figure 5
Three-dimensional plot of the fully factorial for predicted response RT of KPT plotted on -axis as a function of factor. (a) A (flow rate) and B (column temperature); fixed factor: C (% tetrahydrofuran 38.0%). (b) B (column temperature) and C (% tetrahydrofuran); fixed factor: A (flow rate 1.5mL min−1). (c) A (flow rate) and C (% tetrahydrofuran); fixed factor: B (column temperature 50°C). RT of TIN plotted on -axis as a function of factor. (d) A (flow rate) and B (column temperature); fixed factor: C (% tetrahydrofuran 38.0%). (e) B (column temperature) and C (% tetrahydrofuran); fixed factor: A (flow rate 1.5 mL min−1). (f) A (flow rate) and C (% tetrahydrofuran); fixed factor: B (column temperature 50°C). Plate count of KPT plotted on -axis as a function of factor. (g) A (flow rate) and B (column temperature); fixed factor: C (% tetrahydrofuran 38.0%). (h) A (flow rate) and C (% tetrahydrofuran); fixed factor: B (column temperature 50°C). (i) B (column temperature) and C (% tetrahydrofuran); fixed factor: A (flow rate 1.5 mL min−1).
