Development and Validation of a Stability Indicating RP-HPLC Method for the Determination of Two Sun Protection Factors (Koptrizon and Tinosorb S) in Topical Pharmaceutical Formulations Using Experimental Designs
Table 8
ANOVA for 23 full factorial design: response: Koptrizon plate count.
Source
Sum of squares
df
Mean square
value
value Prob >
Model
5139776.375
3
1713258.792
111.8731376
<0.0001
Significant
A—flow
966745.125
1
966745.125
63.12695487
0.0005
B—column temp.
905185.125
1
905185.125
59.1071825
0.0006
C—THF comp.
3267846.125
1
3267846.125
213.3852755
<0.0001
Curvature
65.025
1
65.025
0.004246031
0.9506
Not significant
Residual
76571.5
5
15314.3
Lack of fit
68121.5
4
17030.375
2.015428994
0.4800
Not significant
Pure error
8450
1
8450
Cor total
5216412.9
9
Std. dev.
113.0166101
0.985308578
Mean
3416.1
Adjusted
0.977962866
Values of prob > less than 0.05 indicates that model is significant.
